{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:37:55Z","timestamp":1761007075764,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Corticobasal syndrome is a clinical diagnosis and common pathological causes are corticobasal degeneration, progressive supranuclear palsy and Alzheimer's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We would like to highlight a rare but important differential of corticobasal syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 78\u2010year\u2010old female had a 4\u2010year history of predominantly right\u2010hand rest tremor, worsening of handwriting but no change in cognition. The clinical examination showed right upper limb postural and kinetic tremor, mild wrist rigidity and reduced amplitude of right\u2010sided finger tapping. She was initially diagnosed as idiopathic Parkinson's disease. Five years after onset of symptoms, she demonstrated bilateral myoclonic jerks and right upper limb dystonic posturing. She could not copy movements with the right hand. The magnetic resonance imaging (MRI) revealed disproportionate atrophy in the parietal lobes bilaterally. The clinical diagnosis was changed to probable corticobasal syndrome. She passed away 11\u2009years from onset of symptoms at the age of 85\u2009years. She underwent a post\u2010mortem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anterior and posterior frontal cortex, anterior cingulate, temporal neocortex, hippocampus and amygdaloid complex demonstrated considerable tau\u2010related pathology consisting of a dense background of neuropil threads, and rounded, paranuclear neuronal inclusions consistent with Pick bodies. The immunostaining for three microtubule binding domain repeats (3R) tau performed on sections from the frontal and temporal lobes, basal ganglia and midbrain highlighted several inclusions whilst no 4R tau was observed. She was finally diagnosed with Pick's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pick's disease can rarely present with clinical features of corticobasal syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14125","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T03:30:48Z","timestamp":1717385448000},"page":"1025-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pick's Disease Presenting as Tremulous Parkinsonism with Limited Levodopa Response\u2014A Rare Cause of Corticobasal Syndrome"],"prefix":"10.1002","volume":"11","author":[{"given":"Shakya","family":"Bhattacharjee","sequence":"first","affiliation":[{"name":"Department of Neurology Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust (Salford Royal Hospital)  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Scotton","sequence":"additional","affiliation":[{"name":"Department of Neurology Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Djoukhadar","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust (Salford Royal Hospital)  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne S.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Faculty of Biology, Medicine and Health School of Biological Sciences, The University of Manchester, Salford Royal Hospital  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Minshull","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Faculty of Biology, Medicine and Health School of Biological Sciences, The University of Manchester, Salford Royal Hospital  Salford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2208-7728","authenticated-orcid":false,"given":"Andrew C.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences The University of Manchester  Manchester UK"},{"name":"Geoffrey Jefferson Brain Research Centre The University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Roncaroli","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences The University of Manchester  Manchester UK"},{"name":"Geoffrey Jefferson Brain Research Centre The University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Kobylecki","sequence":"additional","affiliation":[{"name":"Department of Neurology Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust (Salford Royal Hospital)  Salford UK"},{"name":"Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences The University of Manchester  Manchester 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