{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:37:23Z","timestamp":1792089443919,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an accepted therapy for Parkinson's disease (PD) with disabling motor complications. For elderly patients with poorer cognition and postural instability, GPi has been proposed as the preferable DBS target based on expert opinion, arguing GPi\u2010DBS may be less complicated by depression, apathy, worsened verbal fluency, and executive dysfunction, resulting in greater improvement in quality of life (QoL). However, data supporting such patient\u2010tailored approach are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aims were to analyze whether the DBS target influences QoL in a PD cohort and a matched subgroup of frail patients with poor cognitive status and reduced postural stability, and whether other factors affect the QoL outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed a single\u2010center cohort of 138 PD patients who received bilateral STN\u2010DBS (117) or GPi\u2010DBS (21) using the mentioned approach for target selection. All patients underwent standardized clinical evaluations of motor\u2010 and nonmotor signs as well as QoL before and 1 year after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DBS of both targets improved motor signs, dyskinesias, and pain. QoL improved without significant difference between the targets, but with a trend for greater improvement across all QoL domains in favor of the STN, even in an STN subgroup matched to the GPi group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results contradict the prevailing belief that GPi\u2010DBS is superior in frail PD patients with cognitive decline and postural instability, questioning the proposed patient\u2010tailored approach of DBS target selection. Further studies are needed for a data\u2010driven approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14199","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T09:30:23Z","timestamp":1725355823000},"page":"1379-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quality of Life after Deep Brain Stimulation in Parkinson's Disease: Does the Target Matter?"],"prefix":"10.1002","volume":"11","author":[{"given":"Sandra","family":"Murcia Carretero","sequence":"first","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Petermann","sequence":"additional","affiliation":[{"name":"Department of Neurology Bern University Hospital and University of Bern  Bern 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