{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:46Z","timestamp":1792007626760,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tremor is commonly found among healthy humans or prevalently a symptom of neurological dysfunctions. However, the distinction between physiological and pathological tremor is dependent on the examiner's competence. Archimedes Spiral Rating (ASR) is a valid and reproducible semi\u2010quantitative method to assess the severity of action tremor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>(1) To assess the range and percentiles of ASR in a large sample seemingly free of tremor\u2010related conditions or symptoms from the population\u2010based CHRIS\u2010study. (2) To analyze the influence of sex, age, and the drawing hand on ASR. (3) To define ASR limits of normal. (4) To supply exemplary Archimedes spiral drawings by each rating to favor consistent and proficient clinical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Accurately investigated participants were randomly sampled over 14 sex\u2010age strata. 2686 paired spirals drawn with both hands by 1343 participants were expertly assessed on a tremor rating scale from 0 to 9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ASR had a quadratic increase with age in both sexes, while it was relatively lower in the dominant compared to the non\u2010dominant hand and in women compared to men. ASRs above sex\u2010age specific 97.5th percentiles of 4 and 5, below and above 60\u2009years of age, respectively, were conceivably of non\u2010physiological nature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large population\u2010based sample we show a steeper increase of action tremor by age as age progresses. Relatively higher ratings among the elderly, males and the non\u2010dominant hands, appear compatible with ASR limits of \u201cnormal\u201d across sex\u2010age groups. The current operational evidence may support practitioners differentiating physiological and pathological hand tremor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14201","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:17:56Z","timestamp":1725520676000},"page":"1257-1265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Archimedes Spiral Ratings: Determinants and Population\u2010Based Limits of Normal"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-0281","authenticated-orcid":false,"given":"Franziska","family":"Hopfner","sequence":"first","affiliation":[{"name":"Department of Neurology Ludwig\u2010Maximilians University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Tietz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"D'Elia","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research  Bolzano\/Bozen Italy"},{"name":"Prusa Research a.s  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-0109","authenticated-orcid":false,"given":"Cristian","family":"Pattaro","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research  Bolzano\/Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-3155","authenticated-orcid":false,"given":"Jos S.","family":"Becktepe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-4348","authenticated-orcid":false,"given":"Martin","family":"G\u00f6gele","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research  Bolzano\/Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8139-4686","authenticated-orcid":false,"given":"Laura","family":"Barin","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research  Bolzano\/Bozen Italy"},{"name":"Centre for Medical Sciences \u2013 CISMed, University of Trento  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-8302","authenticated-orcid":false,"given":"Peter P.","family":"Pramstaller","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research  Bolzano\/Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-8113","authenticated-orcid":false,"given":"Gregor","family":"Kuhlenb\u00e4umer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kiel University  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4115-317X","authenticated-orcid":false,"given":"Roberto","family":"Melotti","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, Eurac Research  Bolzano\/Bozen Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27121"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20487"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-4231(09)70170-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25648"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23808"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.8.868"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.8.868"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.05.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0704-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050312"},{"key":"e_1_2_9_13_1","unstructured":"D'EliaY.EuracBiomedicalResearch\/DigitalSpiralography: DrawingRecorder\u20101.8.1 [online];Zenodo; 2024. 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