{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T09:53:09Z","timestamp":1794217989578,"version":"4.8.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24HPE\u20101287320"],"award-info":[{"award-number":["24HPE\u20101287320"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["MJFF\u2010020770"],"award-info":[{"award-number":["MJFF\u2010020770"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aimed to determine the cross\u2010sectional and prospective associations between parkinsonism and PD with frailty in a large multi\u2010country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>12,865 older adults (aged \u226565\u2009years) from the 10\/66 population\u2010based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross\u2010sectional association between parkinsonism\/PD with baseline frailty. Individual country analyses were combined via fixed\u2010effect meta\u2010analysis. In non\u2010frail participants who were followed up for 4\u2009years, Cox proportional hazards regression models assessed the prospective association between parkinsonism\/PD with incident frailty accounting for competing risk of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87\u20133.31), 2.42 (95% CIs 1.80\u20133.25), and 1.57 (95% CIs 1.16\u20132.21), and cause\u2010specific hazard ratios were 1.66 (95% CIs 1.07\u20132.56), 1.78 (95% CIs 1.05\u20133.03), and 1.58 (95% CIs 0.91\u20132.74). Similar results were found for parkinsonism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parkinsonism and PD were cross\u2010sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14214","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T01:38:23Z","timestamp":1726882703000},"page":"1489-1499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cross\u2010Sectional and Prospective Associations between Parkinsonism and Parkinson's Disease with Frailty in Latin America"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6605-3338","authenticated-orcid":false,"given":"Dani J.","family":"Kim","sequence":"first","affiliation":[{"name":"Health Service and Population Research Department, Institute of Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience King's College London  London UK"},{"name":"Population Health Sciences Institute, Faculty of Medical Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-0022","authenticated-orcid":false,"given":"Nusrat","family":"Khan","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Faculty of Medical Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Llibre\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Dementia Research Unit Medical University of Havana  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Faculty of Biomedical Sciences Universit\u00e0 della Svizzera italiana  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Rodriguez\u2010Salgado","sequence":"additional","affiliation":[{"name":"Global Brain Health Institute University of San Francisco California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Acosta","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias National Institute of Neurology and Neurosurgery  Mexico City Mexico"},{"name":"National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luisa","family":"Sosa","sequence":"additional","affiliation":[{"name":"Laboratory of the Dementias National Institute of Neurology and Neurosurgery  Mexico City Mexico"},{"name":"National Autonomous University of Mexico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Acosta","sequence":"additional","affiliation":[{"name":"Universidad Nacional Pedro Henriquez Ure\u00f1a (UNPHU), Internal Medicine Department, Geriatric Section  Santo Domingo Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne Z.","family":"Jimenez\u2010Velasquez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Geriatrics Program, School of Medicine, Medical Sciences Campus University of Puerto Rico  San Juan Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Guerra","sequence":"additional","affiliation":[{"name":"Instituto de la Memoria Depresion y Enfermedades de Riesgo IMEDER  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aquiles","family":"Salas","sequence":"additional","affiliation":[{"name":"Medicine Department, Caracas University Hospital, Faculty of Medicine Universidad Central de Venezuela  Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedelys D\u00edaz","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute of Public Health, Faculty of Biomedical Sciences Universit\u00e0 della Svizzera italiana  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"L\u00f3pez\u2010Contreras","sequence":"additional","affiliation":[{"name":"Memory Clinic, Neurology Service Salvadoran Social Security Institute  San Salvador El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Hesse","sequence":"additional","affiliation":[{"name":"Observatorio Covid\u201019 Universidad Tecnol\u00f3gica Centroamericana  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California\u2010San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-7750","authenticated-orcid":false,"given":"Jorge J.","family":"Llibre\u2010Guerra","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Prina","sequence":"additional","affiliation":[{"name":"Health Service and Population Research Department, Institute of Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience King's College London  London UK"},{"name":"Population Health Sciences Institute, Faculty of Medical Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5770\/cgj.24.437"},{"key":"e_1_2_9_3_1","unstructured":"WHO.Parkinson disease; Accessed: Nov 2024 [Online]. Available:https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaa219"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191604"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62167-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-230114"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(18)30091-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00394"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.14362"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.m146"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/53B.1.S9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.7.722"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.10.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10873-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.05.004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492572"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06347-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw056"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-165"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lana.2021.100136"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13384"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1167-4"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.48.5.1277"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0959259802012236"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.04.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckac129.014"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-020-01539-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2017.09.026"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0378-4"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6646-9"},{"key":"e_1_2_9_35_1","unstructured":"FoxJ WeisbergS.Cox Proportional\u2010Hazards Regression for Survival Data in R."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.329"},{"key":"e_1_2_9_38_1","first-page":"85","article-title":"A multivariate technique for multiply imputing missing values using a sequence of regression models","volume":"27","author":"Raghunathan T","year":"2000","journal-title":"Surv Methodol"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429492259"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28561"},{"key":"e_1_2_9_41_1","first-page":"522","article-title":"Sarcopenia and frailty in Parkinson's disease: a case\u2010control study","volume":"25","author":"Peball M","year":"2018","journal-title":"Eur J Neurol"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad075"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00413.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa191"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2021.100095"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:31:59Z","timestamp":1760952719000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/mdc3.14214"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14214","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"2024-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}