{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:06:46Z","timestamp":1793232406922,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alpha\u2010synucleinopathies, such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), demonstrate sex differences with regard to prevalence, age of onset, and motor manifestations. Neuropsychiatric symptoms (NPS) are common early and late manifestations of these disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to describe sex differences in NPS across alpha\u2010synucleinopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched Web of Science Core collection databases to identify observational studies published between January 1, 2000, and June 1, 2022, reporting the prevalence or severity of NPS among individuals with a diagnosis of PD, PDD, or DLB. Prevalence and severity were pooled for each NPS according to sex using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two\u2010hundred\u2010and\u2010forty studies, representing 796,026 participants (45% females), were included in the meta\u2010analysis. Female sex was associated with a higher prevalence of anxiety (OR\u2009=\u20091.60 [95% CI: 1.40, 1.82]), depression (OR\u2009=\u20091.56 [1.45, 1.67]), fatigue (OR\u2009=\u20091.21 [1.02, 1.43]), and psychotic symptoms (OR\u2009=\u20091.26 [1.14, 1.40]) and more severe anxiety (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20091.35 [95% CI: 0.58, 2.13]), depression (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20091.57 [1.05, 2.08]), and fatigue (\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u20090.86 [0.41, 1.32]), while male sex was associated with a higher prevalence of apathy (OR\u2009=\u20090.77 [0.63, 0.93]), impulse control disorders (OR\u2009=\u20090.67 [0.55, 0.82]), REM sleep behavior disorder (OR\u2009=\u20090.54 [0.42, 0.70]), hypersomnolence (OR\u2009=\u20090.67 [0.56, 0.80]), and suicide (OR\u2009=\u20090.30 [0.20, 0.44]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NPS have different prevalences and severities in alpha\u2010synucleinopathies according to sex. These findings support consideration of sex in the elaboration of clinical tools.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14227","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:10:11Z","timestamp":1728555011000},"page":"1335-1344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sex Differences in Neuropsychiatric Symptoms in Alpha\u2010Synucleinopathies: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4054-3820","authenticated-orcid":false,"given":"Vincent","family":"Couture","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Division of Geriatric Psychiatry Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Carmel","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry Institut Universitaire de G\u00e9riatrie de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerine","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Geriatric Psychiatry Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"L\u00e9tourneau","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Geriatric Psychiatry Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Clerc","sequence":"additional","affiliation":[{"name":"Division of Geriatric Psychiatry Institut Universitaire de G\u00e9riatrie de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Huot","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery McGill University  Montr\u00e9al QC Canada"},{"name":"Neurodegenerative Disease Group Montreal Neurological Institute Hospital  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010France","family":"Forget","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc Dinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"Innovation Hub, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-8660","authenticated-orcid":false,"given":"Richard","family":"Camicioli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Neuroscience and Mental Health Institute University of Alberta  Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Desmarais","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Geriatrics Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"},{"name":"Innovation Hub, Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al  Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"879","article-title":"Aggregation of alpha\u2010synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with lewy bodies","volume":"152","author":"Baba M","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.830"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.083113"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25664"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.08.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.03.024"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.104695"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312283"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bf992f"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.02.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.103788"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.04.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.09.025"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.3.181"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.1.33"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.48.5_suppl_6.10s"},{"key":"e_1_2_9_22_1","unstructured":"NIH National Heart Lung and Blood Institute.Quality assessment tool for observational cohort and cross\u2010sectional studies;https:\/\/www.nhlbi.nih.gov\/health\u2010topics\/study\u2010quality\u2010assessment\u2010tools. Accessed 01 June 2022."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4002"},{"key":"e_1_2_9_25_1","volume-title":"IBM SPSS Statistics for Windows, Version 29.0","author":"IBM Corp","year":"2022"},{"key":"e_1_2_9_26_1","volume-title":"Review Manager (RevMan). 5.4","author":"Cochrane Collaboration","year":"2014"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.03.006"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.36"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.6.565"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0920-9964(02)00380-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.4.733"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-00991-z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06185-7"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102367"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00869-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.540781"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101810"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40779"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2704"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.078891"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00697.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.00229.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-9276-8-28"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1980-5764-2016dn1004014"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:29:42Z","timestamp":1760966982000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/mdc3.14227"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14227","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"2024-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}