{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:31:22Z","timestamp":1791747082198,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory dysfunction is an important contributor to morbidity and mortality in advanced Parkinson's disease (PD), but it is unclear what parameters are sensitive to diagnose and monitor respiratory dysfunction across disease phases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to characterize respiratory dysfunction in mild to moderate PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 20 individuals without cardiopulmonary comorbidity, pulmonary and inspiratory muscle function testing were performed ON\u2010medication. Subsequently, the acute ventilatory response to hypoxia (HVR) was assessed by gradually decreasing F\n                      <jats:sub>I<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      from 0.209 (room air) to 0.127, which was compared to eight age\u2010 and sex\u2010matched healthy controls under arterial blood gas monitoring. Lastly, on different days, the same 20 individuals with PD underwent six blinded exposures to 45\u2010min normobaric hypoxia at FiO2 0.163 and 0.127 or placebo OFF\u2010medication to assess breathing responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At rest, individuals with greatest PD severity had a lower tidal volume (pairwise comparisons: 0.59 vs. 0.74,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.038\u20130.050) and tended to have a higher breathing frequency (17.7 vs. 14.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.076), despite normal pulmonary function. A 45\u2010min exposure to hypoxia induced a significantly lower acute HVR in individuals with PD compared to controls (\u22120.0489 vs. 0.133\u2009L.min\/%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.0038). Acute HVR was reduced regardless of disease severity. Subacute HVR in individuals with milder disease tended to be higher compared to those with more advanced disease (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.079).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Respiratory dysfunction is present in individuals with PD, including those with relatively mild disease severity, and is characterized by altered breathing patterns at rest, as well as a lower HVR, despite normal pulmonary and inspiratory muscle function testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14249","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:49:15Z","timestamp":1730789355000},"page":"1550-1558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Respiratory Dysfunction and Abnormal Hypoxic Ventilatory Response in Mild to Moderate Parkinson's Disease"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-5882","authenticated-orcid":false,"given":"Jules M.","family":"Janssen Daalen","sequence":"first","affiliation":[{"name":"Radboud University Medical Center, Department of Neurology Donders Institute for Brain, Cognition and Behavior, Center of Expertise for Parkinson &amp; Movement Disorders  Nijmegen The Netherlands"},{"name":"Department of Medical BioSciences, Department of Physiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel R.","family":"Straatsma","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Department of Physiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen W.H.","family":"van Hees","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Weevers","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Department of Physiology Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Pulmonary Diseases Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle A.","family":"van de Wetering\u2010van Dongen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten J.","family":"Nijkrake","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan J.","family":"Meinders","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Department of Neurology Donders Institute for Brain, Cognition and Behavior, Center of Expertise for Parkinson &amp; Movement Disorders  Nijmegen The Netherlands"},{"name":"Radboud University Medical Center, Radboud Institute for Health Sciences, IQ Healthcare  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank H.","family":"Bosch","sequence":"additional","affiliation":[{"name":"Rijnstate Hospital Department of Internal Medicine  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs","family":"Kox","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"University of British Columbia, Center for Heart, Lung and Vascular Health, School of Health and Exercise Sciences  Kelowna Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Department of Neurology Donders Institute for Brain, Cognition and Behavior, Center of Expertise for Parkinson &amp; Movement Disorders  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick H.J.","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Department of Physiology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15743"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11050595"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86011-w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018969"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160804"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190400"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00724"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00253.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00363.2021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-213121"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02638-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029224"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.09.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02770-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01499-2021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-014-9584-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-022-00533-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14-1-72"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.5.1430"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.11.007"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2014.08.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01932-x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00165-2020"},{"key":"e_1_2_8_25_1","first-page":"1","article-title":"Breathing in parkinsonism in the rat","volume":"884","author":"Bialkowska M","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(98)81208-X"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113735"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2908-11.2012"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01126.2013"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2016.tb00707.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1890-4"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:32:02Z","timestamp":1760952722000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/mdc3.14249"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14249","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2024-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}