{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:11:53Z","timestamp":1790399513492,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with Parkinson's Disease (PD) frequently exhibit non\u2010motor symptoms, particularly sleep disturbances. Sleep disorders in PD patients are intricately linked to the pathogenesis and progression of PD itself, exacerbating neurodegenerative processes and worsening patient quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This review underscores the significance of sleep disorders in PD, highlighting their prevalence, impact on disease progression, and the bidirectional relationship between sleep disruption and neurodegeneration. It aims to enhance clinician awareness for better diagnosis and management of sleep\u2010related comorbidities in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted in PubMed and Scopus using key terms such as \u201csleep disorders\u201d, \u201cParkinson's disease\u201d, \u201cREM sleep behavior disorder\u201d, \u201crestless legs syndrome\u201d, \u201cinsomnia\u201d, \u201cobstructive sleep apnea\u201d, \u201cexcessive daytime sleepiness\u201d, \u201ccircadian rhythm disorders\u201d, \u201csleep and neurodegeneration\u201d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sleep disorders are prevalent in PD affecting up to 90% of patients. Conditions such as insomnia, REM sleep behavior disorder, restless legs syndrome, obstructive sleep apnea, excessive daytime sleepiness, and circadian rhythm disorders are commonly reported. These disorders are linked to multifactorial biological mechanisms and are associated with more severe disease phenotypes. Of note, several evidence shows that sleep abnormalities may contribute to neuroinflammation and neurodegeneration, further accelerating the disease course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sleep disturbances are critical non\u2010motor symptoms in PD. Early diagnosis and tailored management of sleep disorders are essential for improving clinical outcomes and potentially offering neuroprotective benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14254","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T08:58:43Z","timestamp":1730969923000},"page":"11-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-6139","authenticated-orcid":false,"given":"Elena","family":"Antelmi","sequence":"first","affiliation":[{"name":"Neurology Unit B, AOUI  Verona Italy"},{"name":"DIMI Department of Engineering and Medicine of Innovation University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanza","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Research Unit Oasi Research Institute\u2010IRCCS  Troina Italy"},{"name":"Department of Surgery and Medical\u2010Surgical Specialties University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Mogavero","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"San Raffaele Scientific Institute, Division of Neuroscience Sleep Disorders Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-1428","authenticated-orcid":false,"given":"Gloria Pompea","family":"Mingolla","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Plazzi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB)  Bologna Italy"},{"name":"Department of Biomedical, Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Ferini\u2010Strambi","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"San Raffaele Scientific Institute, Division of Neuroscience Sleep Disorders Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6937-3065","authenticated-orcid":false,"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Research Unit Oasi Research Institute\u2010IRCCS  Troina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-7063","authenticated-orcid":false,"given":"Michele","family":"Tinazzi","sequence":"additional","affiliation":[{"name":"Neurology Unit B, AOUI  Verona Italy"},{"name":"Department of Neurosciences, Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav2546"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25702"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101759"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0448-y"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.11.1146"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007500"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.10.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01478-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109568"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2024.07.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105790"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13610"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2019.09.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24752"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228421"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00486-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2018.01.006"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4563"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00176-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad072"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-024-02739-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101745"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S423878"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.03.026"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.113976"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08459-5"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.927994"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12899"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac113"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-191627"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10596"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29402"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12545"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz113"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70287-X"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27200"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25459"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S266071"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.014"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe7099"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-033955"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02952.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04058.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5685-07.2008"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0241-0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.03.012"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-019-0147-y"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01198-1"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-024-01638-y"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112928"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1485-1"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2018"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2021.05.039"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11121588"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092291"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13880"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz242"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10040274"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114281"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000878"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819410-2.00004-7"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14521"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-018-0569-8"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S201994"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm090"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm097"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-019-0514-8"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14569"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020396"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(02)00065-9"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-45295-0_16"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.056622"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023085"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2011.00014"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2012.01027.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.02.012"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301817"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2011.12.003"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.01.002"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2010.00145"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.027"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200303000-00005"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6239"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:25:33Z","timestamp":1760955933000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":85,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/mdc3.14254"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14254","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"2024-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}