{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:00:59Z","timestamp":1782741659014,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["F31\u2010NS129241"],"award-info":[{"award-number":["F31\u2010NS129241"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01\u2010NS081118"],"award-info":[{"award-number":["R01\u2010NS081118"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While deep brain stimulation (DBS) targeting the ventral intermediate nucleus (VIM) of thalamus or posterior subthalamic area (PSA) can suppress forms of action tremor in people with Essential Tremor, previous studies have suggested postural tremor may respond more robustly than kinetic tremor to DBS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we aimed to more precisely quantify the (1) onset\/offset dynamics and (2) steady\u2010state effects of VIM\/PSA\u2010DBS on postural and kinetic tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tremor data from wireless inertial measurement units were collected from 11 participants with ET (20 unilaterally assessed DBS leads). Three postural hold tasks and one kinetic task were performed with stimulation turned off, in 2\u2010min intervals after enabling unilateral DBS at the clinician\u2010optimized DBS setting (15\u2009min), and in 2\u2010min intervals following cessation of DBS (5\u2009min).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, kinetic tremor had significantly higher amplitudes, standard deviation, and frequency than postural tremor (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). DBS had a more robust acute effect on postural tremors (54% decrease, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), with near immediate tremor suppression in amplitude and standard deviation, but had non\u2010significant improvement of kinetic tremor on the population\u2010level across the wash\u2010in period (34% decrease). Tremor response was not equivalent between wash\u2010in and wash\u2010out timepoints and involved substantial individual variability including task\u2010specific rebound or long wash\u2010out effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Programming strategies for VIM\/PSA\u2010DBS should consider the individual temporal and effect size variability in postural versus kinetic tremor improvement. Improved targeting and programming strategies around VIM and PSA may be necessary to equivalently suppress both postural and kinetic tremors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14256","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T08:59:03Z","timestamp":1730969943000},"page":"166-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Differentiating Postural and Kinetic Tremor Responses to Deep Brain Stimulation in Essential Tremor"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2529-5971","authenticated-orcid":false,"given":"Rebecca D.","family":"Butler","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie 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