{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:08:56Z","timestamp":1792033736836,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018996","name":"Hellenic Academic Libraries Link","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loss of dorsolateral nigral hyperintensity (DNH) in iron\u2010sensitive sequences of Magnetic Resonance Imaging (MRI), also described as \u201cswallow tail sign\u201d (STS) loss, has shown promising diagnostic value in Parkinson's Disease (PD) and Atypical Parkinsonian Syndromes (APS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To conduct a bibliometric analysis on substantia nigra MRI and a systematic review on the clinical utility of STS visual assessment on Susceptibility\u2010Weighted Imaging in various clinical entities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>VOSviewer's keyword co\u2010occurrence network was employed using Web of Science (WOS). Complying with the PRISMA statement, we searched MEDLINE, WOS, SCOPUS, ProQuest and Google Scholar for peer\u2010reviewed studies conducted in vivo, excluding quantitative imaging techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DNH is a relatively novel parameter in substantia nigra MRI literature. Our SWI\u2010focused review included 42 studies (3281 patients). Diagnostic accuracy of STS loss for PD\/APS differentiation from controls and for Lewy Body Dementia differentiation from other dementias was 47.8\u201398.5% and 76\u201390%, respectively, with poorer capacity, however, in delineating PD from APS. STS evaluation in idiopathic REM sleep behavior disorder, a sign of prodromal PD, was typically concordant with nuclear scans, identifying subjects with high conversion risk. Iron deposition can affect STS in Multiple Sclerosis and STS loss in Amyotrophic Lateral Sclerosis is linked with multisystem degeneration, with poorer prognosis. In healthy individuals iron\u2010induced microvessel changes are suspected for false positive results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>STS assessment exhibits potential in different settings, with a possibly intermediate role in the diagnostic work\u2010up of various conditions. Its clinical utility should be explored further, through standardized MRI protocols on larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14304","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T07:40:19Z","timestamp":1734421219000},"page":"134-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Is the Swallow Tail Sign a Useful Imaging Biomarker in Clinical Neurology? 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