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The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA\u2010AUT questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the I\u2010PD cohort, GBA\u2010PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA\u2010PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA\u2010PD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I\u2010PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14314","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:11:24Z","timestamp":1734678684000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Parasympathetic Dysfunction Prevails in <scp><i>GBA1<\/i><\/scp>\u2010Associated Parkinson's Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-7428","authenticated-orcid":false,"given":"Tiziana","family":"De Santis","sequence":"first","affiliation":[{"name":"Department of Neurology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoniangela","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Neurology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Life Sciences University of Insubria  Varese Italy"},{"name":"IRCCS Fondazione Don Carlo Gnocchi  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Ferrarin","sequence":"additional","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Mineri","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Morenghi","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, IRCCS Humanitas Research Hospital  Rozzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micol","family":"Avenali","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Parkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-0006","authenticated-orcid":false,"given":"Alberto","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Neurology IRCCS Humanitas Research Hospital  Rozzano Italy"},{"name":"Department of Neurosciences Catholic University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318225ab77"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901281"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28195"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24777"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.842498"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-223197"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13892"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02788.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12921"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.11.024"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25170"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-019-00598-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199301000-00003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21242"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60631-4"},{"issue":"3","key":"e_1_2_8_19_1","first-page":"354","article-title":"Standards of measurement, physiological interpretation, and clinical use. 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