{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:21:03Z","timestamp":1791580863198,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171421"],"award-info":[{"award-number":["82171421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91949118"],"award-info":[{"award-number":["91949118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371266"],"award-info":[{"award-number":["82371266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171252"],"award-info":[{"award-number":["82171252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701250"],"award-info":[{"award-number":["81701250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nowadays, cognitive impairment has been characterized as one of the most vital clinical symptoms in progressive supranuclear palsy (PSP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Based on a relatively large cohort, we aimed to show the cognitive deterioration in different PSP subtypes during 1\u2010year follow\u2010up and investigate potential contributors for disease prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred seventeen patients from Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI) cohort underwent neuropsychological tests and 1\u2010year follow\u2010up, with 73 diagnosed as PSP\u2010Richardson syndrome (PSP\u2010RS) and 44 as PSP\u2010non\u2010RS. Patients were divided into normal cognition (PSP\u2010NC), mild cognitive impairment (PSP\u2010MCI), and PSP\u2010dementia. Cognitive impairment and progression rates were compared between PSP\u2010RS and PSP\u2010non\u2010RS, and determinants for MCI conversion to dementia were calculated by multiple cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 30.8% of PSP patients were diagnosed as dementia, 53.0% as MCI, and only 16.2% as NC. Compared to PSP\u2010non\u2010RS, PSP\u2010RS suffered more from motor symptoms and cognitive impairment. During follow\u2010up, PSP\u2010RS also exhibited faster disease progression in Mini\u2010Mental State Examination and visuospatial function, with cognitive deterioration in attention and executive function, but retained in language and memory subdomains. Twenty\u2010seven of 62 PSP\u2010MCI patients converted to dementia during follow\u2010up, with the diagnosis of RS subtype as the most significant contributor to conversion (hazard ration\u2009=\u20092.993, 95% confidence interval\u2009=\u20091.451, 5.232, <jats:italic>P<\/jats:italic>\u2009=\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with PSP\u2010RS showed more severe cognitive impairment and faster decline longitudinally than patients with PSP\u2010non\u2010RS. Additionally, the diagnosis of RS subtype appears to be the most contributed factor for MCI conversion to dementia within just 1\u2010year follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14315","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T08:38:54Z","timestamp":1735288734000},"page":"475-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rapid Cognitive Deterioration in Progressive Supranuclear Palsy: A 1\u2010Year Follow\u2010Up Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-4825","authenticated-orcid":false,"given":"Xin\u2010Yi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"PET Center Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0494-3597","authenticated-orcid":false,"given":"Gan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Xin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-2202","authenticated-orcid":false,"given":"Xiao\u2010Niu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"},{"name":"Institute of Neurology, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Min","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-395X","authenticated-orcid":false,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1631","authenticated-orcid":false,"given":"Feng\u2010Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology National Clinical Research Center for Aging and Medicine, &amp; National Center for Neurological Disorders, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Progressive Supranuclear Palsy Neuroimage Initiative (PSPNI)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac040"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq158"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000267643.24870.26"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acs098"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.17067"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-019-02065-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25872"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2023.120718"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.09.043"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.06.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052686.97625.27"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30157-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.821570"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10511-y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09324-x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-06104-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-223553"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.788166"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24311"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.652059"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.627356"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.680332"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.684918"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-021-03495-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21507"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479110"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.07.007"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20707"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317443"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101899"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24044"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2019.1670865"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12201"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-314956"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab206"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.07.033"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:37:37Z","timestamp":1760960257000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/mdc3.14315"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14315","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"2024-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}