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Group and correlation analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MA patients had greater GID than DN. GIDS\u2010PD scores directly correlated with MDS\u2010UPDRS\u2010III and non\u2010motor scores in both groups, although more in DN. GIDS\u2010PD scores were directly associated with \u03b1\u2010synuclein and inversely with lymphocytes only in DN; conversely, they were positively associated with tau proteins and albumin ratio, and negatively with amyloid\u2010\u03b2\u2010peptides in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The burden of GID increases along the PD course with associated stage\u2010specific clinical\u2010biological patterns.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14319","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:06:17Z","timestamp":1734678377000},"page":"497-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gastrointestinal Dysfunction Bears on the Clinical\u2010Biological Profile of Parkinson's 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