{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:02:49Z","timestamp":1789124569075,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The cerebral Renin\u2010Angiotensin System might have a role in anxiety and depression development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We explored the effects of Angiotensin II Type 1 receptor blockers (ARBs) and angiotensin\u2010converting enzyme inhibitors (ACE\u2010Is) on anxiety and depression in Parkinson's Disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred and twenty\u2010three newly diagnosed drug\u2010na\u00efve PD patients were evaluated using the State\u2013Trait Anxiety Inventory (STAI) and Geriatric Depression Scale (GDS\u201015) tests and were monitored at baseline and for up to 3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve patients were treated with ARBs and 42 with ACE\u2010Is. ARB\u2010treated patients had lower anxiety STAI scores than those on ACE\u2010Is or drug\u2010free at baseline (17.2\u2009\u00b1\u20091.3 vs. 21.3\u2009\u00b1\u20091.3, or 23.8\u2009\u00b1\u20090.5, respectively, <jats:italic>P<\/jats:italic>\u2009=\u20090.021) and during the follow\u2010up (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Depression scores were unaffected by any of the drugs throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This small sample of ARB\u2010treated PD patients displayed lower levels of anxiety. Randomized clinical trials are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14326","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T04:14:04Z","timestamp":1737173644000},"page":"653-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An Open\u2010Label, Non\u2010randomized, Drug\u2010Repurposing Study to Explore the Clinical Effects of Angiotensin <scp>II<\/scp> Type 1 (<scp>AT1<\/scp>) Receptor Antagonists on Anxiety and Depression in Parkinson's Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2332-2462","authenticated-orcid":false,"given":"Sofia","family":"Bordet","sequence":"first","affiliation":[{"name":"Centro de Altos Estudios en Ciencias Humanas y de la Salud. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas CAECIHS.UAI\u2010CONICET  Buenos Aires Argentina"},{"name":"Centro de Investigaciones en Psicolog\u00eda y Psicopedagog\u00eda (CIPP), Facultad de Psicolog\u00eda y Psicopedagog\u00eda Pontificia Universidad Cat\u00f3lica Argentina (UCA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Grasso","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Psicolog\u00eda y Psicopedagog\u00eda (CIPP), Facultad de Psicolog\u00eda y Psicopedagog\u00eda Pontificia Universidad Cat\u00f3lica Argentina (UCA)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Udovin","sequence":"additional","affiliation":[{"name":"Centro de Altos Estudios en Ciencias Humanas y de la Salud. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas CAECIHS.UAI\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenson","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Centro de Altos Estudios en Ciencias Humanas y de la Salud. Universidad Abierta Interamericana. Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas CAECIHS.UAI\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Otero\u2010Losada","sequence":"additional","affiliation":[{"name":"Centro de Altos Estudios en Ciencias Humanas y de la Salud. Universidad Abierta Interamericana. 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