{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:38:16Z","timestamp":1783391896423,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cerebrospinal fluid (CSF) \u03b1\u2010synuclein seeding activity (SSA) via a seed amplification assay might predict central Lewy body diseases (LBD) in at\u2010risk individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to assess CSF SSA in a prospective, longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants self\u2010reported risk factors were genetics, olfactory dysfunction, dream enactment behavior, orthostatic intolerance, or hypotension; individuals who had \u22653 confirmed risk factors underwent CSF sampling and were followed for up to 7.5\u2009years. Participants who developed a central LBD (LBD+) were compared to those who did not. Quadruplicate SSA areas under the curve (AUC) were averaged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 11 subjects with average AUCs above 500,000\u2009units, 7 (64%) developed a central LBD compared to 1 of 20 (5%), with AUCs below the cutoff value (<jats:italic>P<\/jats:italic>\u2009=\u20090.0011 by log\u2010rank test). Conversely, 7 of 8 (88%) LBD+ participants had elevated initial AUCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased CSF SSA predicts central LBDs. Individuals who develop a central LBD have elevated initial SSA AUCs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.14333","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:27:58Z","timestamp":1737008878000},"page":"659-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated Cerebrospinal Fluid \u03b1\u2010Synuclein Seeding Activity Predicts Central Lewy Body Diseases"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-9940","authenticated-orcid":false,"given":"David S.","family":"Goldstein","sequence":"first","affiliation":[{"name":"Autonomic Medicine Section (AMS), Clinical Neurosciences Program (CNP), Division of Intramural Research (DIR), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH)  Bethesda Maryland 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