{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:08:03Z","timestamp":1779088083795,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023326","name":"Britannia Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although there are established guidelines for the selection of suitable candidates, objective and timely referral for the use of apomorphine remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This research examined how telemonitoring may facilitate referrals for continuous subcutaneous apomorphine infusion in Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Blind Rater and a multi\u2010disciplinary team (MDT) including an expert PD nurse, neurologist, and geriatrician determined apomorphine pump treatment eligibility for 20 patients with PD. The MDT considered telemonitoring data and physical examination to determine eligibility. The Blind Rater used only telemonitoring data (PDMonitor\u00ae) to evaluate eligibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results show that using wearable sensors to determine appropriateness of apomorphine pump treatment is similar to a complete method that combines objective motor symptom monitoring with clinical evaluation. The MDT and blind rater had a 0.89 Cohen's kappa coefficient, which suggests high rate of agreement. The best\u2010performing objective metric for differentiating patients who were recommended (APO) from those non\u2010recommended (non\u2010APO) for apomorphine pump therapy, was the device\u2010reported percentage of time in the \u201cON\u201d state, which takes into consideration the \u201cOFF\u201d and dyskinesia time. The APO group had lower values in this metric and could be differentiated from the non\u2010APO group accurately (85%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Using telemonitoring to determine eligibility for apomorphine therapy might improve evaluation and treatment in patients with PD and, therefore help improve their quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14345","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T08:55:18Z","timestamp":1739264118000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing Eligibility for Apomorphine Therapy in Parkinson's Disease: The Telemonitoring Potential"],"prefix":"10.1002","volume":"12","author":[{"given":"Alagaratnam","family":"Niruban","sequence":"first","affiliation":[{"name":"Norfolk and Norwich University Hospital  Norwich United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaclav","family":"Dostal","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital  Norwich United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Mutimer","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital  Norwich United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Tsamis","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, School of Health Sciences, University of Ioannina  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1297-0691","authenticated-orcid":false,"given":"Spyridon","family":"Kontaxis","sequence":"additional","affiliation":[{"name":"PD Neurotechnology Ltd.  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Kostikis","sequence":"additional","affiliation":[{"name":"PD Neurotechnology Ltd.  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foivos","family":"Kanellos","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, School of Health Sciences, University of Ioannina  Ioannina Greece"},{"name":"PD Neurotechnology Ltd.  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adamantios","family":"Ntanis","sequence":"additional","affiliation":[{"name":"PD Neurotechnology Ltd.  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Rigas","sequence":"additional","affiliation":[{"name":"PD Neurotechnology Ltd.  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5217-1317","authenticated-orcid":false,"given":"Spyridon","family":"Konitsiotis","sequence":"additional","affiliation":[{"name":"University Hospital of Ioannina and Faculty of Medicine, School of Health Sciences, University of Ioannina  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb05016.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181474"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557519666191104110908"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.151179"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.054759"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"2","article-title":"Beyond motor symptom wearing\u2010off in Parkinson's disease \u2013 what have we learned?","volume":"14","author":"Poewe W","year":"2019","journal-title":"Eur Neurol Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00661-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282x20180140"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00525-w"},{"key":"e_1_2_7_11_1","unstructured":"Health fNI Excellence C.Parkinson's disease in adults (NICE guideline NH71);2017."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91531-E"},{"key":"e_1_2_7_13_1","unstructured":"National Health Service.Guidelines For the Treatment Of Parkinson's With Apomorphine (APO\u2010go\u00ae);2023."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105359"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15386"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-024-00325-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02656-z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160830"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246528"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/s23083807"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00585-y"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533798"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1080752"},{"key":"e_1_2_7_24_1","unstructured":"Health fNI Excellence C.Devices for remote continuous monitoring of people with Parkinson's disease (NICE guideline DG51).https:\/\/www.nice.org.uk\/guidance\/dg51\/2023."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21237801"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12010027"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.11.031"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.14345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.14345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:19:45Z","timestamp":1779085185000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.14345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/mdc3.14345"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.14345","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,11]]},"assertion":[{"value":"2024-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}