{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:10:16Z","timestamp":1789171816595,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The new classification of progressive supranuclear palsy (PSP) subtypes necessitates identifying radiological biomarkers to support the clinical diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The goal was to test if magnetic resonance imaging (MRI) morphometry, diffusion tensor imaging (DTI), susceptibility\u2010weighted imaging (SWI), or [18F]fluorodeoxyglucose (\n                      <jats:sup>18F<\/jats:sup>\n                      FDG)\u2010positron emission tomography (PET) differentiates PSP subtypes from each other or Parkinson's disease (PD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Midbrain\/pons (M\/P) area ratio, middle\/superior cerebellar peduncle (MCP\/SCP) width ratio, magnetic resonance parkinsonism indices (MRPI and MRPI2) and midbrain antero\u2010posterior (AP) diameter were measured. Region of interest\u2010based DTI, SWI, and\n                      <jats:sup>18F<\/jats:sup>\n                      FDG\u2010PET analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four PSP subtypes (n\u2009=\u200985) and 24 PD were studied. MRI morphometry and DTI could differentiate PSP\u2010Richardson syndrome (PSP\u2010RS) from PSP\u2010parkinsonism, PSP\u2010postural instability, and PD (area under curve\u2009&gt;0.7). SWI did not differentiate among PSP subtypes or PD.\n                      <jats:sup>18F<\/jats:sup>\n                      FDG\u2010PET distinguished PSP from PD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MRI morphometry and DTI differentiated PSP\u2010RS from the other common PSP subtypes and PD and may be tested as a radiological marker of PSP\u2010RS in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.14346","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T04:58:56Z","timestamp":1738645136000},"page":"664-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multimodality Brain Imaging Markers in\n                    <scp>Progressive Supranuclear Palsy<\/scp>\n                    Subtypes and Parkinson's Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-9144","authenticated-orcid":false,"given":"Kanchana Soman","family":"Pillai","sequence":"first","affiliation":[{"name":"Parkinson and Movement Disorders Centre Department of Neurology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvathy","family":"Rajeswari","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Centre Department of Neurology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra B.","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Radiology Aster CMI Hospital  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shagos","family":"Gopalan Nair Santhamma","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0800-173X","authenticated-orcid":false,"given":"Manas","family":"Chacko","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Centre Department of Neurology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Jayakrishnan","sequence":"additional","affiliation":[{"name":"Department of Radiology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjini","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Radiology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayana","family":"Avarachan","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Centre Department of Neurology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-1544","authenticated-orcid":false,"given":"Asha","family":"Kishore","sequence":"additional","affiliation":[{"name":"Parkinson and Movement Disorders Centre Department of Neurology Aster Medcity  Kochi Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh488"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.47.1.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2453061703"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.07.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0262"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.02.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-012-1132-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27666"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.10.012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.12.030"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321354"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28901"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"WarrenNM PiggotMA PerryEK BurnDJ.Cholinergic systems in progressive supranuclear palsy. 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