{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:14:23Z","timestamp":1791224063070,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Isolated REM sleep behavior disorder (iRBD) indicates an early \u03b1\u2010synucleinopathy with approximately 90% of individuals pheno\u2010converting to Parkinson's disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Recently, prodromal disease definitions (pPD, pDLB, pMSA) have been introduced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the overlap of prodromal definitions in an established iRBD cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We applied the current diagnostic criteria for pPD, pDLB, and pMSA to\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200955 individuals from the local iRBD cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All except two individuals fulfilled at least one of the prodromal disease definitions; most individuals were classified as pPD (94.5%). 56% of the individuals fulfilled more than one definition: 32.7% pMSA&amp;pPD, 10.9% pDLB&amp;pPD, and 12.7% all three (pPD&amp;pDLB&amp;pMSA). The cognitive screening [(pPD\u2009=\u2009pMSA)\u2009&gt;\u2009pDLB], motor symptoms [pPD\u2009&lt;\u2009(pDLB\u2009=\u2009pMSA)], and olfactory testing [(pPD\u2009=\u2009pDLB)\u2009&lt;\u2009pMSA] significantly differed between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The observed overlap leads to challenges in patient counseling and risk disclosure. Better discrimination will facilitate research in early \u03b1\u2010synucleinopathy phases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70006","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T04:33:16Z","timestamp":1740198796000},"page":"828-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Being Prodromal: Current Criteria in the Context of Isolated\n                    <scp>REM<\/scp>\n                    Sleep Behavior Disorder"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-7762","authenticated-orcid":false,"given":"Anja","family":"Ophey","sequence":"first","affiliation":[{"name":"Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne 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