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There is a need to capture the earliest patient experiences in a sensitive and reliable manner for the successful development of interventions that may delay clinical progression in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our aim was to synthesize published literature about patient\u2010reported symptoms in prodromal and early motor stages of PD and develop a conceptual framework of the earliest lived experiences in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a scoping review of the published literature in MEDLINE, EMBASE, SCOPUS, and CINAHL databases and abstracted patient\u2010reported symptoms from included studies reporting on prodromal or early motor stages of PD populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 59 articles with data from 64 cohorts (prodromal PD: n\u2009=\u200920\/64; 31%, early motor PD: n\u2009=\u200944\/64, 69%). Overall, the 10 most frequent symptoms (of 85 standardized reported symptoms [SRSs]) were non\u2010motor. SRSs were grouped into symptom domains (behavioral, cognition, dysautonomia, motor, sensory, sleep, and others) and functional domains (activities of daily living, communication, sexual, and social impairment). The Movement Disorder Society sponsored revision of the Unified Parkinson's Disease Rating Scale parts Ib and II (n\u2009=\u200913\/64, 20%) and ad hoc questionnaires (n\u2009=\u200912\/64, 19%) were the most frequently used measurement tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At prodromal and early motor stages of PD, individuals report symptoms of a diverse range of motor and non\u2010motor domains and higher\u2010level functional domains. There is a need to capture the full spectrum of this lived experience in a new patient\u2010reported clinical outcome measure for clinical trials in the earliest clinical stages of PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70007","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T09:08:32Z","timestamp":1741597712000},"page":"721-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reported Symptoms in Prodromal and Early Motor Parkinson's Disease: A Scoping Review on the Patient Perspective"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5913-3575","authenticated-orcid":false,"given":"Joseph","family":"Saade","sequence":"first","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Division of Neurology, Department of Medicine, Hull Hospital CISSSO  Gatineau Quebec 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