{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:59:13Z","timestamp":1790650753799,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023326","name":"Britannia Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Levodopa\u2013entacapone\u2013carbidopa intestinal gel (LECIG) was introduced in 2018 as a device\u2010aided therapy for advanced Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The ELEGANCE study (NCT05043103) is gathering real\u2010world data on long\u2010term efficacy, safety and patient\u2010reported outcomes with LECIG from 13 European countries. This article reports data from the planned interim analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled patients prescribed LECIG as part of routine clinical care. We evaluated patients at V1 before starting LECIG treatment (in seven patients V1 data were obtained retrospectively), and thereafter at V2 (3\u20136\u2009months) or V3 (6\u201312\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis includes 167 patients from 37 centers. Three patients from this analysis set (1.8%) discontinued the study. Mean (\u00b1SD) daily OFF\u2010time hours (MDS\u2010UPDRS IV item 4.3) were substantially reduced by 3.47\u2009\u00b1\u20093.56\u2009h at V2 (baseline: 5.15\u2009\u00b1\u20093.05; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Similarly, MDS\u2010UPDRS part IV total scores were reduced by 4.24\u2009\u00b1\u20094.08 at V2 (baseline: 10.77\u2009\u00b1\u20093.83); (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001) and MDS\u2010UPDRS part II scores by 3.63\u2009\u00b1\u20097.76 at V2 (baseline: 20.65\u2009\u00b1\u20098.17; <jats:italic>P<\/jats:italic>\u2009=\u20090.0004). PDSS\u20102 total scores were sustainably improved (reduction of 7.38\u2009\u00b1\u200910.72 at V2 [baseline: 25.21\u2009\u00b1\u200910.62]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), as was the PDQ\u20108 summary index score indicating an improvement in quality of life (QoL) (reduction of 13.3\u2009\u00b1\u200919.05 at V2 [baseline: 46.34\u2009\u00b1\u200920.09]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). For all parameters improvements were maintained at V3. Patient\u2010reported satisfaction with the LECIG pump was high. Most adverse events were related to the procedure or the device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine use of LECIG for up to 12\u2009months provided sustained control of motor symptoms, and was well tolerated with a positive impact on QoL and high patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.70046","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T23:48:21Z","timestamp":1743032901000},"page":"1075-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Levodopa\u2013Entacapone\u2013Carbidopa Intrajejunal Infusion in Advanced Parkinson's Disease \u2013 Interim Analysis of the <scp>ELEGANCE<\/scp> Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-7132","authenticated-orcid":false,"given":"Daniel","family":"Weiss","sequence":"first","affiliation":[{"name":"Department 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