{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:23:24Z","timestamp":1786789404834,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["402853\/2012\u20101"],"award-info":[{"award-number":["402853\/2012\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["474748\/2012\u20100"],"award-info":[{"award-number":["474748\/2012\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnostic value of midbrain atrophy for distinguishing behavioral variant frontotemporal dementia (bvFTD) from progressive supranuclear palsy (PSP) is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether measures of midbrain atrophy differentiate PSP from bvFTD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included four groups: healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200919), PSP\u2010Richardson syndrome (<jats:italic>n<\/jats:italic>\u2009=\u200920), bvFTD (<jats:italic>n<\/jats:italic>\u2009=\u200919) and Parkinson's disease (PD; <jats:italic>n<\/jats:italic>\u2009=\u200912). The following quantitative and qualitative measures were calculated: Hummingbird sign rating scale [HBS\u2010RS], global midbrain atrophy [GMA], midbrain area, midbrain\/pons ratio, the Magnetic Resonance Parkinsonism Index (MRPI), the MRPI 2.0 and brainstem volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, PSP and bvFTD had lower values of midbrain area, HBS\u2010RS and GMA, and higher MRPI and MRPI 2.0. HBS\u2010RS, GMA, midbrain\/pons ratio, midbrain area, MRPI, MRPI 2.0 and brainstem volume distinguished PSP from bvFTD with 73%, 67%, 75%, 83%, 71%, 69% and 82% accuracies, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both quantitative and qualitative measures of midbrain atrophy provided modest accuracy in distinguishing PSP from bvFTD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.70058","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T07:06:58Z","timestamp":1743750418000},"page":"1151-1156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy from Frontotemporal Dementia?"],"prefix":"10.1002","volume":"12","author":[{"given":"Mauro C\u00e9sar Quint\u00e3o e Silva","family":"Cunningham","sequence":"first","affiliation":[{"name":"Ambulat\u00f3rio de Dist\u00farbios de Movimento Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Grupo de Neurologia Cognitiva e do Comportamento Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-6783","authenticated-orcid":false,"given":"Sarah Teixeira","family":"Camargos","sequence":"additional","affiliation":[{"name":"Ambulat\u00f3rio de Dist\u00farbios de Movimento Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Neuroci\u00eancias Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"},{"name":"Departamento de Cl\u00ednica M\u00e9dica Faculdade de Medicina da UFMG  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2356-2951","authenticated-orcid":false,"given":"Vin\u00edcius Ribeiro","family":"Jeunon","sequence":"additional","affiliation":[{"name":"Grupo de Neurologia Cognitiva e do Comportamento Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-8082","authenticated-orcid":false,"given":"Natalia Pessoa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Neurology McGovern Medical School, The University of Texas Health Science Center at Houston  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio L\u00facio","family":"Teixeira","sequence":"additional","affiliation":[{"name":"The Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, Long School of Medicine The University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Faculdade Santa Casa BH  Belo Horizonte 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