{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:09:06Z","timestamp":1782270546938,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Motor fluctuations are routinely documented using the Parkinson's disease (PD) home diary. However, the validity of this diary when compared to clinical observers is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study disassembled the effects of nonmotor symptoms (NMS) on inter\u2010method agreement between the PD home motor diary and clinical observers (outside validity criterion).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational VALIDATE\u2010PD cohort study in advanced PD assessing symptom severity by simultaneous hourly ratings using the home diary (Off, On, dyskinetic state) and a nonmotor diary (11\u2009key NMSs) was performed. Test validity measures (accuracy and Cohen's \u03ba) were compared between hours with and without co\u2010occurring NMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred eighty\u2010seven hourly time periods from 47 participants were analyzed. Inter\u2010method agreement (accuracy, Cohen's \u03ba) of the motor diary was independent of co\u2010occurring NMSs, but simultaneous NMSs inversely influence false ratings of motor Off and On states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simultaneously occurring NMSs do not affect general validity but the interpretation of the PD home motor diary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.70061","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T11:25:12Z","timestamp":1743679512000},"page":"979-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Simultaneous Nonmotor Symptoms Do Not Affect General Validity but Interpretation of the Parkinson's Disease Motor Diary"],"prefix":"10.1002","volume":"12","author":[{"given":"Hampus","family":"Andersson","sequence":"first","affiliation":[{"name":"Division of Neurology Department of Clinical Sciences, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bremer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-9817","authenticated-orcid":false,"given":"Florin","family":"Gandor","sequence":"additional","affiliation":[{"name":"Movement Disorder Clinic  Beelitz Germany"},{"name":"Department of Neurology Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ebersbach","sequence":"additional","affiliation":[{"name":"Movement Disorder Clinic  Beelitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-0825","authenticated-orcid":false,"given":"Matthias","family":"L\u00f6hle","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Odin","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Clinical Sciences, Lund University  Lund Sweden"},{"name":"Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-9216","authenticated-orcid":false,"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Rostock  Rostock Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) 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