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However, there is little research on how PwP perceive the impact of drooling and what factors contribute to it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective was to evaluate the self\u2010perceived impact of drooling in people with and without Parkinson's disease and the contributing clinical factors in PwP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional and case\u2010control study. Participants were clinically examined, and the primary outcome was the Sialorrhea Clinical Scale for Parkinson's disease. Clinical variables were compared between PwP and control subjects using the Mann\u2010Whitney test, correlations between drooling impact and clinical factors in PwP were analyzed using Spearman's test, and predictors were identified using linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 101 PwP and 101 sex\u2010 and age\u2010matched controls. PwP experienced significantly more severe impact of drooling compared to\u00a0controls across all domains: diurnal and nocturnal drooling, drooling severity and frequency, social discomfort, speech, and eating impairments. The greater impact of drooling in PwP was significantly associated with drooling severity, disease duration, levodopa equivalent daily dose, clinical global impression of saliva accumulation (CGI\u2010S), chewing, swallowing, speech, oromotor, motor and non\u2010motor impairments. Significant predictors of greater impact of drooling in PwP include drooling severity, higher CGI\u2010S, facial expression, and swallowing impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PwP have a significantly greater impact of drooling compared to controls, affecting several domains. Drooling impact and its contributing clinical factors should be investigated in a Parkinson's consultation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.70077","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T08:30:16Z","timestamp":1745224216000},"page":"1113-1123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self\u2010Perception of Drooling Impact in People with Parkinson's Disease: A Case\u2013Control and Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-4660","authenticated-orcid":false,"given":"David","family":"Nascimento","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina Universidade de Lisboa  Lisbon Portugal"},{"name":"Swallowing Disorders Unit, Department of Otolaryngology, Hospital de Egas Moniz Unidade Local de Sa\u00fade de Lisboa 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