{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:34:54Z","timestamp":1791311694112,"version":"4.3.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine whether speech characteristics can serve as a digital biomarker to differentiate between MSA and PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010one MSA patients and 23 PD patients underwent a battery of speech assessments: text reading, sustained phonation and diadochokinetic tasks. Speech characteristics were extracted using the software, Praat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MSA and PD speech can be described by three meaningful factors. MSA speech exhibited more reading pauses, higher pitch variability, prolonged syllables, and a more irregular speech rhythm, allowing differentiation from PD with a ROC\u2010AUC of 0.89. Speech characteristics were correlated with motor impairment and disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MSA can be differentiated from PD with good accuracy using speech analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70094","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T04:48:46Z","timestamp":1746247726000},"page":"1391-1396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Speech Differences between Multiple System Atrophy and Parkinson's Disease"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-2399","authenticated-orcid":false,"given":"Tom","family":"H\u00e4hnel","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD \u2010 Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nemitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty and University Hospital Carl Gustav Carus TUD \u2010 Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Kliniken Beelitz GmbH  Beelitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Berger","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Kliniken Beelitz GmbH  Beelitz Germany"},{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg 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