{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:21:25Z","timestamp":1789597285849,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031205","name":"Harquail Centre for Neuromodulation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Historically, staged bilateral thalamotomy has been associated with cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine cognitive outcomes of second\u2010sided focused ultrasound (FUS) thalamotomy in individuals with medication\u2010refractory essential tremor (ET) who previously underwent unilateral FUS thalamotomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010one individuals with medication\u2010refractory ET completed cognitive testing before undergoing second\u2010sided FUS thalamotomy and 4 months post\u2010FUS. Cognitive changes were analyzed at the group and individual levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the group level, no significant declines were observed on any of the test scores. At the individual level, most cognitive test scores remained stable (95% of scores), with declines (2% of scores) and improvements (3% of scores) occurring infrequently. Specifically, declines were observed on only four of the 19 cognitive test scores. No more than two participants declined on any single test score and no participant declined on more than two cognitive test scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Second\u2010sided FUS thalamotomy is associated with minimal risk of cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70095","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T09:23:47Z","timestamp":1745400227000},"page":"1385-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cognitive Outcomes Following Second\u2010Sided Focused Ultrasound Thalamotomy for Tremor"],"prefix":"10.1002","volume":"12","author":[{"given":"Silina Z.","family":"Boshmaf","sequence":"first","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Petersen","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute, West Virginia University School of Medicine  Morgantown West Virginia USA"},{"name":"Department of Psychiatry Harvard Medical School at Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohina","family":"Kumar","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8390-8393","authenticated-orcid":false,"given":"Nadia","family":"Scantlebury","sequence":"additional","affiliation":[{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute  Toronto Ontario Canada"},{"name":"Harquail Centre for Neuromodulation, Sunnybrook Research 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