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To date very little is known about loneliness in Parkinson's disease (PD) and focal\/segmental craniocervical dystonia (FSCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To explore whether level of loneliness is disease\u2010specific by comparing PD, FCSD and healthy controls (HCs), and to define predictors of loneliness in both PD and FSCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010two people with PD, 63 people with FSCD and 50 HC were surveyed. The UCLA Loneliness Scale was used to assess loneliness. Various non\u2010motor symptoms, psychosocial variables and measures of subjective well\u2010being were assessed and used as potential predictors of loneliness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in reported levels of loneliness between people with PD and matched HCs, and between people with PD and people with FSCD, but people with FSCD reported higher levels of loneliness than HCs (<jats:italic>p<\/jats:italic>\u2009=\u20090.018). Perceived stigma predicted loneliness in both disease groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Additionally, non\u2010motor symptoms (<jats:italic>p<\/jats:italic>\u2009=\u20090.006), lack of optimism (<jats:italic>p<\/jats:italic>\u2009=\u20090.015) and practical social support (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) predicted loneliness in people with PD. Patients with PD and FSCD with higher perceived stigma levels felt lonelier (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), as did female patients with PD (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), younger patients with FSCD (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) and older patients with PD (<jats:italic>p<\/jats:italic>\u2009=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified important predictors of loneliness in PD and FSCD. The identified age\u2010 and gender\u2010specific differences in loneliness in people with PD and FSCD contribute to our better understanding of this complex and not yet fully understood concept.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mdc3.70098","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:39:32Z","timestamp":1745901572000},"page":"1302-1312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of Loneliness in Parkinson's Disease and Craniocervical Dystonia"],"prefix":"10.1002","volume":"12","author":[{"given":"Suzette","family":"Shahmoon","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London 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