{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T18:22:00Z","timestamp":1794075720332,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["404460098606"],"award-info":[{"award-number":["404460098606"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical trials in spinocerebellar ataxias (SCA) require objective, quantifiable outcome measures sensitive to changes in disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective was to study the sensitivity to change of digital gait biomarkers in SCA1 over a 1\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventeen SCA1 patients and 15 controls walked 30\u2009seconds wearing 3 sensors at 3 walking speeds (preferred, slow, fast) at baseline and 1\u2010year follow\u2010up. Relationship between gait and clinical measures was analyzed, and standardized response means (SRMs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Toe\u2010off angle (TOA), variability in TOA, speed, and stride length showed significant responsiveness (SRM\u2009=\u2009\u22121.15, 0.61, \u22120.77, and \u22120.85). TOA, which correlated most strongly with ataxia severity and patient\u2010reported outcomes, demonstrated higher sensitivity to change than Scale for Assessment and Rating of Ataxia (SARA) in early\u2010stage disease at preferred walking speed. Gait variability measures lacked sensitivity, possibly due to the short recording period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Digital gait biomarkers are promising outcomes in future clinical trials in SCA1, but their sensitivity to change appears stage dependent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70124","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T07:05:33Z","timestamp":1746601533000},"page":"1622-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal Assessment Reveals Stage\u2010Dependent Utility of Digital Motor Markers in\n                    <scp>SCA1<\/scp>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2095-3488","authenticated-orcid":false,"given":"Ilse H.J.","family":"Willemse","sequence":"first","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-0801","authenticated-orcid":false,"given":"Teije","family":"van Prooije","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten C.J.","family":"Kapteijns","sequence":"additional","affiliation":[{"name":"Department of Neurology Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart P.C.","family":"van de 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