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Current treatment options are limited by side effects and accessibility. Electroacupuncture (EA), a non\u2010pharmacological approach, has shown promise in insomnia, while its specific impact on insomnia in PD remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the efficacy and safety of EA vs sham electroacupuncture (SA) on insomnia associated with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter, participant\u2010and assessor\u2010blinded, randomized, sham\u2010controlled clinical trial from March 1, 2024, to October 28, 2024, across eight sites in China. A total of 136 PD patients with insomnia were assigned to receive EA or SA (68 per arm) over an 8\u2010week treatment period followed by a 12\u2010week follow\u2010up period. The primary outcome was the change in Parkinson's Disease Sleep Scale (PDSS) scores at week 8. A range of subjective sleep\u2010related metrics and objective sleep assessments derived from polysomnography were utilized as secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both groups showed significant improvements in PDSS scores, with the EA group demonstrating a greater effect (between\u2010group difference, 13.50 [95%CI, 12.68 to 14.32]). Secondary outcomes, including Insomnia Severity Index, Epworth Sleepiness Scale, and polysomnography\u2010derived parameters, also showed greater improvements in EA group. The effects were maintained during the 12\u2010week follow\u2010up with no severe adverse events. The blinding assessment confirmed successful blinding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EA was effective in improving insomnia and related sleep disturbances in PD. This study provided Class I evidence supporting the integration of EA into the treatment regimen for insomnia in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70139","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T04:09:30Z","timestamp":1748405370000},"page":"1589-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and Safety of Electroacupuncture on Insomnia in Parkinson's Disease: A Multicentre, Randomized, Controlled Trial"],"prefix":"10.1002","volume":"12","author":[{"given":"Si\u2010Chun","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Neurology Longhua Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center Longhua Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Longhua Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Emergency Shuguang Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology Gongli Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai 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and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jue","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology Longhua Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Longhua Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology Longhua Hospital, Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Lei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of 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