{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:08:47Z","timestamp":1763474927791,"version":"3.45.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thermoregulation is critical for preventing hyperthermia during physical activity. In Huntington's disease (HD), research on possible thermoregulatory alterations has received little attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to investigate and compare skin temperature differences before and after exercise between HD patients and healthy controls. Additionally, we aimed to evaluate potential correlations between thermoregulation, body composition, and HD severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a cross\u2010sectional study. HD severity was assessed using the Total Functional Capacity and Unified HD rating scales. Skin temperature was assessed using thermographic infrared imaging of standardized 13 anatomical locations on the trunk and upper and lower extremities at baseline and after a treadmill test. Resting oxygen consumption was measured by indirect calorimetry. Differences between groups and correlation analyses between alterations in skin temperature and body composition, and HD severity were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 14 patients with mild\u2013moderate HD, mean age 60.5 (32\u201368) years, and 10 healthy\u2010matched controls, mean age 56 (29\u201365) years. Although, similar thermoregulation capacity was observed between HD patients and controls, uniquely in HD, reduced temperature recovery after exercise was inversely correlated with body mass index (particularly fat mass), resting oxygen consumption, and CAG repeats, and positively correlated with age and quality of life (mental health domain).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although thermoregulation appears to remain largely intact in patients with mild to moderate HD, it tends to decline with aging, CAG repeat expansion, and lower BMI, which may negatively impact overall well\u2010being in HD patients. However, further research with larger sample sizes is essential to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70149","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T02:34:31Z","timestamp":1748572471000},"page":"1784-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preserved Thermoregulation in Huntington's Disease: Insights from an Observational Case\u2013Control Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-7316","authenticated-orcid":false,"given":"Luc\u00eda","family":"Sim\u00f3n\u2010Vicente","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine Rey Juan Carlos University  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Rivadeneyra\u2010Posadas","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Burgos por la Investigaci\u00f3n de la Salud (FBIS), Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Soto\u2010C\u00e9lix","sequence":"additional","affiliation":[{"name":"Endocrinolog\u00eda y Nutrici\u00f3n. Servicio Medicina Interna. Hospital Reina Sof\u00eda. \u00c1rea de Salud de Tudela. Servicio Navarro de Salud \u2013 Osasunbidea  Navarra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Raya\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Deporte y Educaci\u00f3n F\u00edsica para el Desarrollo Personal y Social (GIDEPSO), Department of Specific Didactics, Faculty of Education Sciences and Psychology University of C\u00f3rdoba  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rodr\u00edguez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"VALFIS Research Group, Institute of Biomedicine (IBIOMED), Faculty of Sciences of Physical Activity and Sports, Universidad de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Castillo\u2010Alvira","sequence":"additional","affiliation":[{"name":"Valoraci\u00f3n del Rendimiento Deportivo, Actividad F\u00edsica y Salud y Lesiones Deportivas (REDAFLED), Faculty of Education, University of Valladolid  Soria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario de Burgos  Burgos Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-1182","authenticated-orcid":false,"given":"Esther","family":"Cubo","sequence":"additional","affiliation":[{"name":"Neurology Department Hospital Universitario de Burgos  Burgos Spain"},{"name":"Department of Health Sciences University of Burgos  Burgos Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050272"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12841"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"17","article-title":"How to estimate body composition in Huntington's disease. 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