{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:17:17Z","timestamp":1789154237831,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Rett syndrome (RTT) is a rare neurodevelopmental disorder linked with\n                      <jats:italic>MECP2<\/jats:italic>\n                      variants, frequently presenting with movement disorders (MDs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study examined the frequency, types, and associations of MDs with RTT characteristics and severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty female patients (median age 11\u2009years, range 3\u201340) with\n                      <jats:italic>MECP2<\/jats:italic>\n                      variants were recruited and assessed using disease severity and MD scales, alongside videotaped neurological examinations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Prevalent MD was hypokinetic in 55% of the patients and hyperkinetic in 45%. Parkinsonism and dystonia were the most common, coexisting in 75% of patients. Higher Movement Disorders\u2010Childhood Rating Scale (MD\u2010CRS) scores correlated with greater severity on the Rett Assessment Rating Scale (RARS) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04). Dystonia was significantly associated with respiratory (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) and gastrointestinal problems (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study identified parkinsonism and dystonia as the prevalent MDs in RTT, emphasizing the association between dystonia and gastrointestinal\/respiratory problems and reflecting the complex nature of MDs in RTT.<\/jats:p>\n                  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