{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:40:52Z","timestamp":1790797252676,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinson's disease (PD) places a high burden on patients, their families, healthcare systems, and society as a whole, which is rising due to the increasing prevalence of PD. There has been wide variation in the items included in previous cost of illness (COI) studies for PD, possibly underestimating the costs associated with this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to undertake a detailed estimate of the COI of PD in the Netherlands from a societal perspective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between November 2022 and May 2023, we conducted a cross\u2010sectional COI study with a bottom\u2010up, prevalence\u2010based approach. Data were collected using a questionnaire with a recall period of three months. Costs were valued following the Dutch guideline for economic evaluations in healthcare and extrapolated to costs per year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010four patients were included, with a mean age of 65.9\u2009years and a mean disease duration of 6.3\u2009years. Patients in early disease stages were over\u2010represented. COI was determined at \u20ac 14,487 per patient per year. Healthcare accounted for 55.6% of costs, followed by productivity loss (23.9%) and costs to patients and families (20.5%). The most impactful cost item was medication, followed by social productivity loss, informal care, auxiliary therapy, and work productivity loss. Alternative valuation methods for productivity led to an estimated COI of \u20ac 36,867.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PD\u2010COI was 30\u201340% higher than previously determined in comparable patient groups, probably due to a more comprehensive measurement of costs. Future COI studies in PD should adopt a societal perspective and include all relevant cost items.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70165","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:37:59Z","timestamp":1749451079000},"page":"1849-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Bottom\u2010Up Analysis of the Cost of Illness of Parkinson's Disease in the Netherlands from a Societal Perspective"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1858-5428","authenticated-orcid":false,"given":"Anke","family":"Wijers","sequence":"first","affiliation":[{"name":"Care and Public Health Research Institute (CAPHRI), Department of Health Services Research Maastricht University  Maastricht the Netherlands"},{"name":"Zuyderland Medical Centre, Department of Neurology  Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia M.A.A.","family":"Evers","sequence":"additional","affiliation":[{"name":"Care and Public Health Research Institute (CAPHRI), Department of Health Services Research Maastricht University  Maastricht the Netherlands"},{"name":"Institute of Mental Health and Addictions, Centre of Economic Evaluation Trimbos Institute  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Tissingh","sequence":"additional","affiliation":[{"name":"Zuyderland Medical Centre, Department of Neurology  Heerlen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislaine A.P.G.","family":"van Mastrigt","sequence":"additional","affiliation":[{"name":"Care and Public Health Research Institute (CAPHRI), Department of Health Services Research Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2019.07.031"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.07.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/erp.11.106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb01512.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00038-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181474"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ip.6.3.177"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29995"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2015.1103184"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29718"},{"key":"e_1_2_9_13_1","article-title":"Systematic review and critical analysis of cost studies associated with Parkinson's disease","author":"Bovolenta TM","year":"2017","journal-title":"Parkinsons Dis"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10433-006-0028-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2010.00699.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462321001732"},{"issue":"1","key":"e_1_2_9_17_1","article-title":"A consensus\u2010based checklist for the critical appraisal of cost\u2010of\u2010illness (COI) studies","volume":"39","author":"Schnitzler L","year":"2023","journal-title":"Int J Technol Assess Health Care"},{"key":"e_1_2_9_18_1","unstructured":"Parkinson Vereniging (Dutch Parkinson's Association).https:\/\/www.parkinson-vereniging.nl\/vereniging\/over-ons\/parkinson-vereniging"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-021-01048-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25571"},{"key":"e_1_2_9_21_1","first-page":"A550","volume-title":"Handleiding iMTA Medical Cost Questionnaire (iMCQ)","author":"Bouwmans C","year":"2013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.05.009"},{"key":"e_1_2_9_23_1","volume-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"Drummond M","year":"2016"},{"key":"e_1_2_9_24_1","unstructured":"Zorginstituut Nederland.Richtlijn voor het uitvoeren van economische evaluaties in de gezondheidzorg herziene versie 2024;2024. 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Available from:https:\/\/www.zorginstituutnederland.nl\/publicaties\/publicatie\/2024\/01\/16\/richtlijn\u2010voor\u2010het\u2010uitvoeren\u2010van\u2010economische\u2010evaluaties\u2010in\u2010de\u2010gezondheidszorg."},{"key":"e_1_2_9_26_1","unstructured":"Nederlandse Zorgautoriteit: Tarieven Huisartsendienstenstructuren; Available fromhttps:\/\/puc.overheid.nl\/nza\/doc\/PUC_761066_22\/1\/(visited May 27 2024 last edited February 1 2024)."},{"key":"e_1_2_9_27_1","article-title":"Cost of living with Parkinson's disease over 12 months in Australia: A prospective cohort study","author":"Bohingamu Mudiyanselage S","year":"2017","journal-title":"Parkinsons Dis"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcad056"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-20423-x"},{"key":"e_1_2_9_30_1","unstructured":"https:\/\/www.medicijnkosten.nl\/(visited May 16 2024 last edited May 1 2024)."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-018-0416-4"},{"key":"e_1_2_9_32_1","unstructured":"Centraal bureau voor de statistiek.Werkzame beroepsbevolking; arbeidsduur 2003\u20132022; Available from:https:\/\/www.cbs.nl\/nl-nl\/cijfers\/detail\/82647NED(visited May 27 2024 last edited August 17 2022)."},{"key":"e_1_2_9_33_1","volume-title":"Kostenhandleiding: Methodologie van kostenonderzoek en referentieprijzen voor economische evaluaties in de gezondheidszorg","author":"Hakkaart\u2010van Roijen L","year":"2016"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26217"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2018.09.2156"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2017.0832"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci23-0085"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-019-01119-1"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:04:40Z","timestamp":1763474680000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/mdc3.70165"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70165","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"2025-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}