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Patients with constipation were generally older, white, women, had\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      &gt;5\u2009years, and had higher\n                      <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>\n                      and comorbidity scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Constipation was significantly associated with worse motor symptoms and most\n                      <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>\n                      , especially fecal incontinence (odds ratio [\n                      <jats:styled-content style=\"fixed-case\">OR]<\/jats:styled-content>\n                      =\u20091.65; 95% confidence interval [CI], 1.49\u20131.82), dysphagia (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      =\u20091.20; 95% CI\u2009=\u20091.12\u20131.29), talking\/moving during sleep (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      =\u20091.39; 95% CI\u2009=\u20091.30\u20131.48), and urinary urgency (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      =\u20091.23; 95% CI\u2009=\u20091.16\u20131.32). Constipation was associated with a small, but statistically significant increased risk of some progressive motor symptoms. At a mean median follow\u2010up of 2.8\u2009years, constipation was associated with an increased risk of incident gastrointestinal, autonomic, neuropsychiatric, sleep\u2010related, sensory\n                      <jats:styled-content style=\"fixed-case\">NMS<\/jats:styled-content>\n                      , such as dysphagia (hazard ratio [\n                      <jats:styled-content style=\"fixed-case\">HR]<\/jats:styled-content>\n                      =\u20091.43; 95% CI\u2009=\u20091.35\u20131.51), fecal incontinence (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      =\u20091.87; 95% CI\u2009=\u20091.74\u20132.01), falls (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      =\u20091.44; 95% CI\u2009=\u20091.35\u20131.52), hallucinations (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      =\u20091.65; 95% CI\u2009=\u20091.52\u20131.79), cognitive impairment (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      =\u20091.38; 95% CI\u2009=\u20091.30\u20131.47), and talking\/moving during sleep (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      =\u20091.65; 95% CI\u2009=\u20091.55\u20131.75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Constipation is a common symptom associated with severity of motor and other NMS and portends a worse prognosis in persons with PD.<\/jats:p>\n                  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