{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:14:45Z","timestamp":1787498085975,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Demoralization is a pervasive yet under\u2010recognized syndrome that manifests as profound hopelessness, helplessness, loss of motivation and purpose, and impaired coping capacity. Affecting over one\u2010third of individuals in medical and neurological settings and 20\u201330% of the general population, demoralization is frequently misclassified as depression. However, its distinct phenomenology necessitates precise differentiation, particularly in Parkinson's disease (PD), where it can profoundly impact quality of life (QoL), social engagement, and treatment adherence, potentially contributing to a desire for hastened death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize the limited empirical and conceptual literature on demoralization in idiopathic PD, delineating its prevalence, phenomenology, and clinical\u2013psychosocial correlates, clarifying distinctions from depression and apathy, and deriving evidence\u2010informed recommendations for screening and intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A targeted search of MEDLINE, Embase, PsycINFO, and Web of Science (inception\u201322 May 2025), augmented by manual reference screening, identified eligible empirical and conceptual studies on demoralization in idiopathic PD, which were appraised against predefined criteria and thematically synthesized due to design heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven papers were identified that fit the search criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This paper explores the clinical distinction between demoralization and depression in PWP and presents evidence\u2010based intervention strategies. A compassionate, multidisciplinary, and personalized approach that incorporates the social and psychological aspects of PD may mitigate demoralization, supporting QoL and enhancing functional outcomes throughout disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70209","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:04:22Z","timestamp":1751349862000},"page":"71-79","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["From Hopelessness to Hope: Addressing Demoralization in Parkinson's Disease"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7834-1743","authenticated-orcid":false,"given":"Bradley","family":"McDaniels","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Health Services University of North Texas  Denton Texas 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