{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:52:37Z","timestamp":1775011957941,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Levodopa\u2010carbidopa intestinal gel infusion (LCIG) is an effective therapy for advanced Parkinson's disease (PD). Opicapone (OPC) is an enzyme inhibitor that enhances the bioavailability of levodopa in the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study evaluates the effect of Opicapone addition in PD\u2010LCIG patients, assessing its impact on motor fluctuations and dyskinesias. Secondly, the study analyses the impact of OPC on non\u2010motor symptoms, LCIG dosage, and peripheral neuropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this pilot study, 22 PD patients on LCIG were randomized to receive OPC or not, based on persistent or reemergent fluctuations. The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS), Unified Dyskinesia Rating Scale (UDysRS), Montreal Cognitive Assessment (MoCA), electroneurography (ENG), LCIG doses, homocysteine, vitamin B12, and folic acid levels were measured at baseline (T0) and after 12\u2009months (T1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven patients added OPC (addOPC group), while 11 maintained standard treatment (nOPC group). At baseline, both groups had similar disease duration and severity. At T1, the addOPC group showed significant: (i) improvement in motor fluctuations evaluated by the MDS\u2010UPDRS part IV; (ii) reduction in dyskinesias (UDyRS); (iii) decrease in LCIG infusion rate; (iv) improvement in motor and non\u2010motor symptoms (MDS\u2010UPDRS parts I\u2010III); (v) increase in Vitamin B12. No significant differences were observed in the ENG data, and no serious adverse events occurred. Four addOPC patients (36%) discontinued OPC after 15\u2009\u00b1\u20092\u2009months, mainly due to hallucinations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OPC addition appeared well tolerated and beneficial in reducing motor fluctuations, dyskinesia, and LCIG dose. Randomized controlled trials are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70231","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:00:17Z","timestamp":1752570017000},"page":"2034-2042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Opicapone in Parkinson's Disease on Levodopa\u2010Carbidopa Intestinal Gel Treatment: A Pilot, Randomized Study"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-8153","authenticated-orcid":false,"given":"Fabiana","family":"Colucci","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Ferrara  Ferrara Italy"},{"name":"Parkinson and Movement Disorders Unit, Department of Clinical Neurosciences Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-791X","authenticated-orcid":false,"given":"Andrea","family":"Gozzi","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Ferrara  Ferrara Italy"},{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliero\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Antenucci","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Ferrara  Ferrara Italy"},{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliero\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Casetta","sequence":"additional","affiliation":[{"name":"IRCCS San Camillo Hospital  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Maistrello","sequence":"additional","affiliation":[{"name":"IRCCS San Camillo Hospital  Venice Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-6418","authenticated-orcid":false,"given":"Annibale","family":"Antonioni","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Ferrara  Ferrara Italy"},{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliero\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela Maria","family":"Raho","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliero\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginevra","family":"Tecilla","sequence":"additional","affiliation":[{"name":"APSS Ospedale S. Maria del Carmine  Rovereto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay Guido","family":"Capone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliero\u2010Universitaria S. Anna  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6434-5433","authenticated-orcid":false,"given":"Mariachiara","family":"Sensi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation Azienda Ospedaliero\u2010Universitaria S. 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