{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:40:13Z","timestamp":1790970013305,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>MDS\u2010UPDRS Severity Levels (SLs), derived from clinician\u2010 and patient\u2010rated scales, remain underused to evaluate response to subthalamic deep brain stimulation (STN\u2010DBS) in patients with Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate MDS\u2010UPDRS SL as markers of STN\u2010DBS response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SLs were categorized as mild, moderate, or severe using established cut\u2010off points for Parts II, III Off, and IV. Improvement was defined as a decrease in at least one SL. Part III Off improvement was correlated to quality\u2010of\u2010life scales and used to predict SL improvement using ROC Curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 51 patients (34.1% female, aged 58.9\u2009\u00b1\u200910.2\u2009years, disease duration 12.3\u2009\u00b1\u20094.1\u2009years) were evaluated 12\u2009months after surgery. MDS\u2010UPDRS III Off changes over 30% predicted SL improvements in MDS\u2010UPDRS II (AUC\u2009=\u20090.83,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015) and IV (AUC\u2009=\u20090.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that improvement in MDS\u2010UPDRS SL are potential markers of STN\u2010DBS response. With an MDS\u2010UPDRS part III improvement around 30% predicting SL improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70244","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T09:30:36Z","timestamp":1753176636000},"page":"2324-2329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of\n                    <scp>DBS<\/scp>\n                    Outcome by\n                    <scp>MDS<\/scp>\n                    \u2010\n                    <scp>UPDRS<\/scp>\n                    Severity Levels: Comparison with Changes on\n                    <scp>MDS<\/scp>\n                    \u2010\n                    <scp>UPDRS III<\/scp>"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-2535","authenticated-orcid":false,"given":"Sergio A.","family":"Castillo\u2010Torres","sequence":"first","affiliation":[{"name":"Servicio de Movimientos Anormales, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Cruz","sequence":"additional","affiliation":[{"name":"Servicio de Movimientos Anormales, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malco","family":"Rossi","sequence":"additional","affiliation":[{"name":"Servicio de Movimientos Anormales, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Wilken","sequence":"additional","affiliation":[{"name":"Servicio de Movimientos Anormales, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"},{"name":"Servicio de Neurofisiolog\u00eda Cl\u00ednica, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cerquetti","sequence":"additional","affiliation":[{"name":"Servicio de Movimientos Anormales, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-7823","authenticated-orcid":false,"given":"Marcelo","family":"Merello","sequence":"additional","affiliation":[{"name":"Servicio de Movimientos Anormales, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"},{"name":"Servicio de Neurofisiolog\u00eda Cl\u00ednica, Departamento de Neurolog\u00eda Fleni  Buenos Aires Argentina"},{"name":"Facultad de Ciencias M\u00e9dicas Pontificia Universidad Cat\u00f3lica Argentina  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29066"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27372"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28599"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00223-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.764308"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13379"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.604433"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14147"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.10.026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.6.1142"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199907)14:4<572::AID-MDS1005>3.0.CO;2-C"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29679"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"issue":"3","key":"e_1_2_8_17_1","first-page":"34","article-title":"The measurement of persistent dyskinesia by piezoelectric recording and clinical rating scales","volume":"13","author":"Chien CP","year":"1977","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/26.5.353"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","unstructured":"BeckAT SteerRA BrownG.Beck depression inventory\u2013II; Psychological assessment1996.","DOI":"10.1037\/t00742-000"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.4.2.134"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8040060"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0145-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2017.09.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.20079"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13466"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:20:49Z","timestamp":1773030049000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/mdc3.70244"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70244","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2024-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}