{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:47:19Z","timestamp":1790005639698,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Foslevodopa\/foscarbidopa (LDp\/CDp) significantly reduced motor fluctuations in people with Parkinson's disease (PwP) in clinical trials, but its real\u2010world tolerability and optimal dosing remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess tolerability, dosing patterns, and modifications to concomitant medication with LDp\/CDp in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center retrospective cross\u2010sectional analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The LDp\/CDp was initiated in 53 PwP (41% women, mean age 66\u2009\u00b1\u200911.3\u2009years, mean disease duration 14.1\u2009\u00b1\u20095.7\u2009years, median H&amp;Y 4 (3\u20135); history of cognitive impairment: 40%, history of psychosis: 62%, previous device aided therapies failure: 39%). After an optimization period (18.4\u2009\u00b1\u20096.8\u2009days), the mean Base hourly infusion rate was significantly higher than recommended (0.39\u2009\u00b1\u20090.18 vs. 0.32\u2009\u00b1\u20090.13\u2009ml\/h,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and the LDp\/CDp was co\u2010administered with MAO\u2010B\u2010inhibitors (50%), COMT\u2010inhibitors (44%), and dopamine agonists (12%). Adverse events occurred in 40%: skin reactions (31%), psychosis (8%), falls (2%), and nausea (2%). Thirteen patients discontinued therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LDp\/CDp may be an effective and well\u2010tolerated non\u2010surgical option for managing motor fluctuations in PD, though higher dosing and combination therapy are often required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70249","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T09:34:21Z","timestamp":1753695261000},"page":"2317-2323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Foslevodopa\/Foscarbidopa Continuous Subcutaneous Infusion in Parkinson's Disease: Real\u2010World Short\u2010Term Data on Tolerability, Infusion Rate Adjustments and Concomitant Medication"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-5058","authenticated-orcid":false,"given":"Katarina","family":"Rukavina","sequence":"first","affiliation":[{"name":"Movement Disorders Hospital Beelitz  Beelitz\u2010Heilst\u00e4tten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Ebersbach","sequence":"additional","affiliation":[{"name":"Movement Disorders Hospital Beelitz  Beelitz\u2010Heilst\u00e4tten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doreen","family":"Gruber","sequence":"additional","affiliation":[{"name":"Movement Disorders Hospital Beelitz  Beelitz\u2010Heilst\u00e4tten Germany"},{"name":"Medical faculty Health and Medical University Potsdam  Potsdam Germany"},{"name":"Department of Neurology Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg 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