{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:14:14Z","timestamp":1773814454440,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019138","name":"Mundipharma Medical Company, Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022222","name":"Parkinson Schweiz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022222","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pain (i.e. &gt; 3 months) is a common nonmotor symptom in patients with Parkinson's disease (PD), but the attribution to PD is critical for further treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We explored the PD Pain Classification System (PD\u2010PCS) criteria for the diagnosis of PD\u2010related pain and mutual influences between PD\u2010related and PD\u2010unrelated pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this multicenter study, 120 nondemented PD patients were assessed using the PD\u2010PCS as well as motor and nonmotor questionnaires. The PD\u2010PCS consists of 3 steps: first, it classifies chronic pain as unrelated or related to PD according to 1 of 4 criteria (at onset or aggravated by PD, in the\n                      <jats:italic>off<\/jats:italic>\n                      phase, improvement with dopaminergic treatment, and with dyskinesia); second, it allows the classification of pain mechanisms (neuropathic, nociceptive, and nociplastic); and finally, it provides a score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chronic pain was present in 92% of patients, with PD\u2010related pain in 73% and non\u2010PD\u2010related pain in 53%. Higher PD\u2010PCS scores were reported when PD\u2010related pain was present. In cases of concurrent PD\u2010related and PD\u2010unrelated pain (35%), there was a moderate correlation between pain severity. Improvement with dopaminergic medication and pain in the\n                      <jats:italic>off<\/jats:italic>\n                      phases were the most common factors defining an association of pain with PD. These factors often occur together, whereas pain during dyskinesia occurs independently.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PD\u2010PCS criteria allow differentiation between PD\u2010related and PD\u2010unrelated chronic pain through 2 approaches, assessing periods of either low or high dopaminergic stimulation. PD\u2010unrelated pain should also be taken into account, as it is more common than in the general population and as it may influence PD\u2010related pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70262","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T07:23:51Z","timestamp":1755674631000},"page":"464-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distinction and mutual Influences between Parkinson's Disease\u2010related and unrelated Chronic Pain"],"prefix":"10.1002","volume":"13","author":[{"given":"Jonathan","family":"Hunger","sequence":"first","affiliation":[{"name":"Department of Neurology Center for Neurorehabilitation  Valens Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Brugger","sequence":"additional","affiliation":[{"name":"Department of Neurology Kantonsspital  St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"K\u00e4gi","sequence":"additional","affiliation":[{"name":"Department of Neurology Kantonsspital  St. Gallen Switzerland"},{"name":"Department of Neurology Inselspital, Bern University Hospital, and University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Carsten","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Neurology Philipps University  Marburg Germany"},{"name":"Parkinson Center, Center for Neurological Rehabilitation  Zihlschlacht Switzerland"},{"name":"Service of Neurology and Stroke Unit HFR Fribourg\u2013Cantonal Hospital  Fribourg Switzerland"},{"name":"Service de Neuror\u00e9adaptation HFR Meyriez\u2010Murten  Meyriez Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Hollenstein","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Neurorehabilitation  Valens Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1049-9533","authenticated-orcid":false,"given":"David H.","family":"Benninger","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"},{"name":"Center for Parkinson and Movement Disorders  Reha Rheinfelden Switzerland"},{"name":"Department of Neurology University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-7063","authenticated-orcid":false,"given":"Michele","family":"Tinazzi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien F.","family":"Bally","sequence":"additional","affiliation":[{"name":"Service of Neurology, Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Gonzenbach","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Neurorehabilitation  Valens Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-632X","authenticated-orcid":false,"given":"Daniel","family":"Ciampi de Andrade","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Faculty of Medicine, Center for Neuroplasticity and Pain (CNAP), Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9069-6512","authenticated-orcid":false,"given":"Santiago","family":"Perez Lloret","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Ciencias de la Salud, Fundaci\u00f3n H.A Barcel\u00f3, Consejo de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Buenos Aires Argentina"},{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-0491","authenticated-orcid":false,"given":"Veit","family":"Mylius","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Neurorehabilitation  Valens Switzerland"},{"name":"Department of Neurology Philipps University  Marburg Germany"},{"name":"Department of Neurology Kantonsspital Graub\u00fcnden  Chur Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001384"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00033-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.12.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-202088"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.05.020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2013.08.022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000779"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8426-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22868"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-018-0567-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.105787"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2016.09.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20844"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21596"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27862"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28507"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2023-332551"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26270"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002968"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23429"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10656"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(87)91074-8"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.01.005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.07.013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29943"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000492"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081118"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689809100704"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00393-7"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000507"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.24227"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.07.005"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2024.102994"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22716"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.06.001"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22142"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.107123"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.756538"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2172"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003138"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20629"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.120212"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23825"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.145995"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91674-0"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22874"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22111"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116905"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-021-00867-1"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.2"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13430"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.745"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12217"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mdc3.70262","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:12:02Z","timestamp":1773029522000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/mdc3.70262"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70262","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"value":"2330-1619","type":"print"},{"value":"2330-1619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}