{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:23:40Z","timestamp":1772994220820,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09116"],"award-info":[{"award-number":["21K09116"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K12298"],"award-info":[{"award-number":["24K12298"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reprogramming of chronic deep brain stimulation (DBS) in Parkinson's disease is often underutilized despite potential clinical benefit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to assess the impact of systematic reprogramming in patients with long\u2010term subthalamic nucleus (STN) DBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten patients with long\u2010term STN\u2010DBS underwent systematic reprogramming due to recurrence of motor symptoms or increased medication needs. Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) Part III scores (medication\n                      <jats:italic>off<\/jats:italic>\n                      \/DBS ON) and levodopa equivalent daily dose (LEDD) were compared across initial programming, pre\u2010reprogramming, and post\u2010reprogramming using repeated\u2010measures analysis of variance (ANOVA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Reprogramming yielded a significant 24% improvement in MDS\u2010UPDRS Part III scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) without significant LEDD change. Imaging revealed that reprogramming commonly engaged dorsolateral or supra\u2010STN regions by increasing amplitude or changing from bipolar to monopolar settings while maintaining contact pairs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Systematic reprogramming can improve long\u2010term motor outcomes in STN\u2010DBS. Imaging may assist in understanding and guiding effective reprogramming strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70281","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T07:03:35Z","timestamp":1754636615000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Benefits of Reprogramming Chronic Subthalamic Stimulation in Parkinson's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Jumpei","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Medical Research Institute Kitano Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-0167","authenticated-orcid":false,"given":"Yuwa","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical Research Institute Kitano Hospital  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