{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:36:30Z","timestamp":1791671790097,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Status dystonicus is a life\u2010threatening movement disorder emergency characterized by frequent or prolonged severe episodes of generalized dystonia. The phenomenology, etiology, and outcome is heterogenous and poorly characterized, making implementation of a standardized management approach challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We characterized demographics of children with status dystonicus in a tertiary children's hospital pediatric intensive care unit (PICU), management patterns, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical records at our PICU were searched via ICD\u201010 codes, and we also searched the charts of those with severe dystonia known to our clinical service. We included cases admitted to PICU from 2014 to 2024 who had dystonia severity grade 3\u20135, those with dystonia worse than their baseline, and with age greater than 30\u2009days old, corrected for gestational age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 79 clinical records were screened; 41 admissions from 19 unique patients were included. Mean age was 7.6\u2009\u00b1\u20094.2\u2009years; 53% were female. Most patients had a genetic etiology (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098, 42%). The presenting complaint per admission was often not dystonia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924, 59%); infection was the most common trigger (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923, 56%) followed by pain (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096, 15%). Patients received several anti\u2010dystonia medications (mean 6.9\u2009\u00b1\u20092.5), including clonidine, enteral or IV benzodiazepines, IV ketamine, and others. Median PICU stay was 7\u2009days (interquartile range 3\u201314\u2009days); 37% had multiple PICU admissions. Two patients (4.9%) died from status dystonicus complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Status dystonicus is a life\u2010threatening emergency commonly triggered by pain or infection in patients with dystonia. Given the considerable morbidity and mortality, multi\u2010disciplinary teams should consider standardized treatment guidelines for these complex patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70282","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T10:24:50Z","timestamp":1754648690000},"page":"2247-2252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric Status Dystonicus: A Single\u2010Center 10\u2010Year Retrospective Review"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-6551","authenticated-orcid":false,"given":"Dakota J.S.J.","family":"Peacock","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Pediatrics BC Children's Hospital, University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshvi","family":"Vithlani","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Queen's University  Kingston Ontario Canada"},{"name":"Faculty of Medicine BC Children's Hospital Research Institute, University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Faculty of Medicine BC Children's Hospital Research Institute, University of British Columbia  Vancouver British Columbia Canada"},{"name":"Faculty of Science University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Critical Care, Department of Pediatrics BC Children's Hospital, University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshaya Ann","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Pharmacy BC Children's and Women's Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Horvath","sequence":"additional","affiliation":[{"name":"Division of Biochemical Genetics, Department of Pediatrics BC Children's Hospital, University of British Columbia  Vancouver British Columbia 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