{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:03:26Z","timestamp":1785020606162,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018889","name":"Multiple System Atrophy Coalition","doi-asserted-by":"publisher","award":["MSAC\u20102022\u201012\u2010007"],"award-info":[{"award-number":["MSAC\u20102022\u201012\u2010007"]}],"id":[{"id":"10.13039\/100018889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple system atrophy (MSA) is a relentlessly progressive neurodegenerative disorder with no cure. While therapeutic education programs (TEPs) benefit many chronic conditions, data in MSA are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the feasibility and satisfaction of a mixed in\u2010person\/virtual TEP for early\u2010stage MSA patients and caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A six\u2010module, self\u2010paced TEP was co\u2010developed over 2\u2009years by MSA healthcare professionals, patients, and education experts. A prospective pilot study enrolled recently diagnosed MSA patients (\u226412\u2009months) and caregivers. Primary outcomes were recruitment and retention rates. Secondary outcomes included disease progression (UMSARS I\u2013II), health\u2010related quality of life (Hr\u2010QoL), compared to matched controls not enrolled in the TEP and patients\u2019 satisfaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen patient\u2010caregiver pairs were enrolled. Recruitment and retention rates were 44% and 86%, respectively; 78% of modules were completed (least consulted was disease progression). Disease severity and Hr\u2010QoL worsened over 12\u2009months, with no significant differences versus controls. Overall, 90% of participants were satisfied or very satisfied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our pilot study shows that a mixed TEP for MSA patients and familial caregivers is feasible and able to engage them over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70283","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:53:12Z","timestamp":1754473992000},"page":"1900-1908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and Feasibility of a Mixed Virtual and in\u2010Presence Therapeutic Education Program for Early Multiple System Atrophy Patients"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-592X","authenticated-orcid":false,"given":"Margherita","family":"Fabbri","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS\u2010Park\/F\u2010CRIN Network University of Toulouse 3, CHU of Toulouse, INSERM  Toulouse France"},{"name":"Toulouse NeuroImaging Center University of Toulouse, Inserm, UPS  Toulouse France"},{"name":"MSA French Reference Center Univ. Hospital Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Harroch","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS\u2010Park\/F\u2010CRIN Network University of Toulouse 3, CHU of Toulouse, INSERM  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Camgrand","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS\u2010Park\/F\u2010CRIN Network University of Toulouse 3, CHU of Toulouse, INSERM  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-3611","authenticated-orcid":false,"given":"Paulo Andr\u00e9 Dias","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS\u2010Park\/F\u2010CRIN Network University of Toulouse 3, CHU of Toulouse, INSERM  Toulouse France"},{"name":"MSA French Reference Center Univ. Hospital Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2172-7527","authenticated-orcid":false,"given":"Wassilios G.","family":"Meissner","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, Service de Neurologie des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, CRMR AMS, IMNc  Bordeaux France"},{"name":"Univ. Bordeaux, CNRS, IMN UMR 5293  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christine","family":"Llorca","sequence":"additional","affiliation":[{"name":"AGO Formation  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Travere","sequence":"additional","affiliation":[{"name":"UTEP, Univ. Hospital Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Kermorgant","sequence":"additional","affiliation":[{"name":"MSA French Reference Center Univ. Hospital Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1410-6397","authenticated-orcid":false,"given":"Olivier","family":"Rascol","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Neurosciences, Toulouse Parkinson Expert Centre, Toulouse NeuroToul Center of Excellence in Neurodegeneration (COEN), French NS\u2010Park\/F\u2010CRIN Network University of Toulouse 3, CHU of Toulouse, INSERM  Toulouse France"},{"name":"Toulouse NeuroImaging Center University of Toulouse, Inserm, UPS  Toulouse France"},{"name":"MSA French Reference Center Univ. Hospital Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Leung","sequence":"additional","affiliation":[{"name":"MSA French Reference Center Univ. 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