{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:39:15Z","timestamp":1785512355260,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the\n                      <jats:italic>huntingtin<\/jats:italic>\n                      gene on chromosome 4, leading to progressive cognitive decline, motor impairment, and functional disability. Although balance impairment is recognized in HD, its onset and evolution with disease stage remain poorly understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to track the onset and evolution of balance impairment in HD with progression of disease stage using the BTrackS Balance Plate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Total body sway (TBS) was assessed in 123 gene\u2010positive participants and 33 healthy controls (HC) using the BTrackS Balance Plate and laptop software. The prognostic index\u2013derived Huntington's Disease Integrated Staging System (HD\u2010ISS) was used to stratify these subjects into stage 0\/1 (n\u2009=\u200951), stage 2 (n\u2009=\u200938), and Stage 3 (n\u2009=\u200934). Nonparametric receiver operating characteristic curve analysis was used to compute optimal cutoff values for TBS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Balance assessment revealed significant differences in TBS between HCs and gene\u2010positive participants (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). TBS varied significantly across disease stages (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), with mean values of 9.56\u2009cm (stage 0\/1), 14.46\u2009cm (stage 2), and 28.26\u2009cm (Stage 3). The comparison between HCs and stage 0\/1 individuals revealed strong discrimination (area under the curve [AUC]\u2009=\u20090.709), with a threshold of 7.72\u2009cm achieving 74.5% sensitivity. The most robust discrimination emerged between stage 2 and Stage 3 participants (AUC\u2009=\u20090.71), with a threshold of 11.85\u2009cm at 82.4% sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, this cross\u2010sectional study demonstrates that balance impairment is an early and progressive feature of HD, detectable even before the onset of overt motor symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70288","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T06:41:29Z","timestamp":1757400089000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Using a Brief Body Sway Assessment Device to Track Balance Differences across the Huntington's Disease Integrated Staging System Spectrum"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6553-0944","authenticated-orcid":false,"given":"Japleen","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of neuroscience UC San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeen","family":"Youhanan","sequence":"additional","affiliation":[{"name":"Department of neuroscience UC San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6438-1844","authenticated-orcid":false,"given":"Krisha","family":"Bagga","sequence":"additional","affiliation":[{"name":"Department of neuroscience UC San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of neuroscience UC San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Goble","sequence":"additional","affiliation":[{"name":"Exercise Science, Oakland University  Rochester Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Corey\u2010Bloom","sequence":"additional","affiliation":[{"name":"Department of neuroscience UC San Diego  San Diego California 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