{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:51:42Z","timestamp":1785340302899,"version":"3.55.0"},"reference-count":100,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Pregnancy after a Parkinson's diagnosis presents complex challenges. Due to the paucity of literature, there is no evidence\u2010based guidelines and protocols for preconception care, management of pregnancy, childbirth and the postpartum period in women with early\u2010onset Parkinson's disease (PD). Decision\u2010making can be fraught with uncertainty for both patients and healthcare providers.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This review is aimed to provide pragmatic advice to help guide women with PD before, during and after pregnancy, and to address key gaps in the existing literature.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n An interdisciplinary working group of movement disorder specialists, obstetricians, perinatal neuropsychiatrists, physiotherapist, pharmacist and individuals with lived experiences collaborated to assess published evidence. In areas lacking robust data, recommendations were derived from case studies, registries, clinical and personal expertise.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Key recommendations include:\n \n \n \n Motor Symptom Management:<\/jats:bold>\n Levodopa remains the safest treatment during the perinatal period. Monotherapy is preferred over polypharmacy.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Non\u2010Motor Symptom Management:<\/jats:bold>\n Some non\u2010motor symptoms are particularly common in this patient group and warrant individualized care.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Preconception Considerations:<\/jats:bold>\n Proactive planning about medical management should be done before conception. Genetic counseling and screening should be provided if desired.\n <\/jats:p>\n <\/jats:list-item>\n \n \n Peripartum and Postpartum Considerations:<\/jats:bold>\n The decision regarding mode of delivery should be based upon women's birth plans and obstetric indications. Breastfeeding should be cautiously considered depending on the need for pharmacological treatment.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This article provides a framework for managing PD before, during and after pregnancy. Collaborative efforts and ongoing registries like PregSpark* will be important to develop robust, evidence\u2010based guidelines in this unique population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.70289","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:01:54Z","timestamp":1755680514000},"page":"44-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Management of Parkinson's Disease Before, during and after Pregnancy\u2014an\n MDS<\/scp>\n Scientific Issues Committee Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-7010","authenticated-orcid":false,"given":"Alexander C.","family":"Lehn","sequence":"first","affiliation":[{"name":"Department of Neurology Princess Alexandra Hospital Brisbane Queensland Australia"},{"name":"Faculty of Health, School of Biomedical Sciences Queensland University of Technology Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Metropolitan Government\u2013Seoul National University Boramae Medical Center, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Patterson","sequence":"additional","affiliation":[{"name":"Forensic Medicine Queensland, Department of Health Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Morton","sequence":"additional","affiliation":[{"name":"University of Queensland Brisbane Queensland Australia"},{"name":"Department of Obstetric Medicine and Endocrinology Mater Hospital Brisbane Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pun","sequence":"additional","affiliation":[{"name":"Metro North Mental Health Service, Royal Brisbane and Women's Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3363-0370","authenticated-orcid":false,"given":"Walaa A.","family":"Kamel","sequence":"additional","affiliation":[{"name":"Neurology Department, Faculty of Medicine Beni \u2010Suef University Beni Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9025-137X","authenticated-orcid":false,"given":"Marina","family":"Picillo","sequence":"additional","affiliation":[{"name":"Center for Neurodegenerative Diseases (CEMAND). 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