{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:25:45Z","timestamp":1791318345598,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Parkinsonism\u2010hyperpyrexia syndrome (PHS) is a rare but life\u2010threatening complication in Parkinson's disease (PD), typically triggered by abrupt withdrawal of dopaminergic therapy. It can also occur following deep brain stimulation (DBS) failure, most often due to battery depletion. Limited access to elective neurological care during the COVID\u201019 pandemic increased the risk of such DBS\u2010related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases<\/jats:title>\n                    <jats:p>We present seven patients with advanced PD who developed PHS following DBS battery depletion during the COVID\u201019 pandemic. All patients exhibited motor deterioration, autonomic symptoms, and elevated creatine phosphokinase levels. Despite varied outcomes, five patients recovered following urgent battery replacement and supportive care. Two patients died due to delayed intervention and systemic complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Literature Review<\/jats:title>\n                    <jats:p>A review of 38 published cases of PHS following DBS failure revealed that to date, it has occurred in patients with more than 11\u2009years of PD and at least 2\u2009years of DBS. IPG battery depletion was the leading cause of failure (68.4%), with 76.3% of patients recovering after timely device replacement. Delayed or absent intervention was associated with higher mortality, underscoring the importance of prompt diagnosis and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Timely intervention, remote monitoring, and virtual follow\u2010up are critical to prevent PHS, especially during healthcare disruptions like the COVID\u201019 pandemic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70320","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T09:57:41Z","timestamp":1759139861000},"page":"248-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Parkinsonism\u2010Hyperpyrexia Syndrome Following Deep Brain Stimulation Battery Depletion during the\n                    <scp>COVID<\/scp>\n                    \u201019 Pandemic: A Case Series and Review of the Literature"],"prefix":"10.1002","volume":"13","author":[{"given":"Seyed Amir Hassan","family":"Habibi","sequence":"first","affiliation":[{"name":"Department of Neurology Hazrat Rasool Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-8732","authenticated-orcid":false,"given":"Negin","family":"Eissazade","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Iran University of Medical Sciences  Tehran Iran"},{"name":"Brain and Cognition Clinic, Institute for Cognitive Sciences Studies  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayebe","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Department of Neurology Hazrat Rasool Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8868-7366","authenticated-orcid":false,"given":"Mansour","family":"Parvaresh\u2010Rizi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Hazrat Rasool Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamali","family":"Shahidi","sequence":"additional","affiliation":[{"name":"Department of Neurology Hazrat Rasool Hospital, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5409-1804","authenticated-orcid":false,"given":"Mohammad","family":"Rohani","sequence":"additional","affiliation":[{"name":"Department of Neurology Hazrat Rasool Hospital, Iran University of Medical Sciences  Tehran Iran"},{"name":"Skull Base Research Center, Five Senses Health Institute, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-229122"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prdoa.2024.100246"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2023.101943"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.17816\/ACEN.1095"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.aian_517_23"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2022.09.008"},{"issue":"9","key":"e_1_2_9_8_1","article-title":"Parkinsonism\u2010hyperpyrexia syndrome: a case series and literature review","volume":"14","author":"Azar 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