{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:40:49Z","timestamp":1775652049081,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008262","name":"Harboefonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008262","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009908","name":"Grosserer L. 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The primary outcome was \u03b1SynD detection in skin and olfactory mucosa. Secondary outcomes included prodromal LBD symptoms: cognitive dysfunction, rapid eye movement sleep behavior disorder (RBD), motor and nonmotor symptoms (Movement Disorders Society\u2010Unified Parkinson's Disease Rating Scale [MDS\u2010UPDRS] Parts I\u2013III), and prodromal PD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We recruited 44 iOD participants (mean age 65) and 50 HCs (mean age 67). Eighteen iOD participants (41%) were \u03b1SynD positive in skin and\/or olfactory mucosa compared to 1 HC (2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). iOD participants had higher rates of cognitive dysfunction (48% vs. 24%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02), possible RBD (41% vs. 16%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01), and elevated MDS\u2010UPDRS I\u2013III (median [interquartile range]: 15 [7\u201322] vs. 5.5 [3\u201311],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Dysautonomia symptoms did not differ significantly. In the iOD group, 45% met probable\/possible prodromal PD criteria versus 1 control (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). However, \u03b1SynD\u2010\u03b1SynD\u2010negative iOD participants had a nonsignificantly higher prodromal PD risk compared to \u03b1SynD\u2010positive individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>iOD exhibits high \u03b1SynD prevalence and prodromal LBD symptoms, supporting its role as an early LBD marker and potential model for early intervention and mechanistic studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70333","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T09:16:34Z","timestamp":1757322994000},"page":"494-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prodromal Lewy Body Symptoms and \u03b1\u2010Synuclein Seeding in Idiopathic Olfactory Dysfunction"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-8773","authenticated-orcid":false,"given":"Oskar Hoffmann","family":"McWilliam","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remarh","family":"Bsoul","sequence":"additional","affiliation":[{"name":"Department of Pathology, Danish Reference Center for Prion Disease Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen Gregers","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja Hvid","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Storm N\u00e6sborg","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Dementia Research Centre Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Otolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper","family":"Aan\u00e6s","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and 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