{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:08:35Z","timestamp":1763474915058,"version":"3.45.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chewing dystonia is a rare, task\u2010specific oromandibular dystonia that causes involuntary jaw and tongue movements during mastication and often refractory to standard treatments for dystonia. Emerging evidence suggests that peripheral sensory modulation may play a role in dystonia pathophysiology, but this has not been systematically evaluated as potential treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to explore the therapeutic and neurophysiological effects of intraoral topical lidocaine in patients with task\u2010specific chewing dystonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospectively documented exploratory case series included 6 patients (4 Yemeni males, 2 Indian females), with chewing dystonia unresponsive to medications or botulinum toxin. Two cases were previously reported; 4 were subsequently documented using a uniform clinical protocol. Unified Dystonia Rating Scale (UDRS) scores were assessed before and after intraoral lidocaine during chewing of hard and soft foods. All patients were video recorded; 3 underwent electromyography (EMG). Burst duration and root mean square amplitude were analyzed. Wilcoxon signed\u2010rank tests assessed significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean UDRS scores improved significantly for both hard\u2010consistency foods (7.17\u2009\u00b1\u20090.75 to 3.83\u2009\u00b1\u20090.69;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031) and soft\u2010consistency foods (4.6\u2009\u00b1\u20090.62 to 2.25\u2009\u00b1\u20090.96;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.031). Inter\u2010rater reliability was high. EMG data showed reductions in root mean square (RMS) amplitude ranging between 18.6% and 36.5% across 3 patients alongside visual shortening of burst durations. Symptom relief occurred within minutes, lasted 60\u201390\u2009minutes, and was observed across both balm and spray formulations without adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoral lidocaine may provide rapid, noninvasive relief in task\u2010specific chewing dystonia. These findings support further investigation into sensory\u2010based therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70341","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:26:22Z","timestamp":1756794382000},"page":"1933-1941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chewing Dystonia and Sensory Modulation: An Exploratory Study of Intraoral Lidocaine Effects"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0200-1835","authenticated-orcid":false,"given":"Anish","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Neurology Ramaiah Medical College and Hospitals, Ramaiah University of Applied Sciences  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-161X","authenticated-orcid":false,"given":"Prabhudev M.","family":"Hiremath","sequence":"additional","affiliation":[{"name":"Department of Neurology Ramaiah Medical College and Hospitals, Ramaiah University of Applied Sciences  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2743-0473","authenticated-orcid":false,"given":"Chandrasekhar","family":"Enuguri","sequence":"additional","affiliation":[{"name":"Department of Neurology Ramaiah Medical College and Hospitals, Ramaiah University of Applied Sciences  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1574-1803","authenticated-orcid":false,"given":"Immanni Soma Mani","family":"Giridhar","sequence":"additional","affiliation":[{"name":"Department of Neurology Ramaiah Medical College and Hospitals, Ramaiah University of Applied Sciences  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6932-2528","authenticated-orcid":false,"given":"Thyagarajan","family":"Shivashanmugam","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Iqure Health Sciences Private Limited  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6575-424X","authenticated-orcid":false,"given":"Michiko K.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Parkinson's and Movement Disorder Center, The Queen's Medical Center"},{"name":"John A. Burns School of Medicine, University of Hawai\u02bbi  Honolulu Hawaii USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-7965","authenticated-orcid":false,"given":"Mahendra","family":"Javali","sequence":"additional","affiliation":[{"name":"Department of Neurology Ramaiah Medical College and Hospitals, Ramaiah University of Applied Sciences  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"25","article-title":"Khat consumption as a modifiable risk factor for chewing dystonia","volume":"7","author":"Mehta A","year":"2024","journal-title":"Ann Mov Disord"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.162107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V39N9p740"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-218956"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316250"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/aomd.aomd_51_22"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307316"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2015.07.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10327"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.10.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2005.01.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2003.10.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.06.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef163"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2017.09.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380206"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-45295-0_72"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10142"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.11.062"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000580"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.025"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.02.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2014.5385"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105806"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00944-0"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.06.016"},{"key":"e_1_2_8_28_1","article-title":"Psychological traits and Behavioural influences in patients with dystonia\u2014an observational cohort study in a Romanian neurology department","volume":"11","author":"Davidescu EI","year":"2021","journal-title":"Life (Basel)"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-2-47"}],"container-title":["Movement Disorders Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mdc3.70341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:03:37Z","timestamp":1763474617000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mdc3.70341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/mdc3.70341"],"URL":"https:\/\/doi.org\/10.1002\/mdc3.70341","archive":["Portico"],"relation":{},"ISSN":["2330-1619","2330-1619"],"issn-type":[{"type":"print","value":"2330-1619"},{"type":"electronic","value":"2330-1619"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}