{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:33:52Z","timestamp":1788176032297,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with Huntington's disease (HD) commonly experience anosognosia, a lack of awareness of disease\u2010specific deficits. However, how early anosognosia begins in the course of HD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the onset of anosognosia in HD by exploring its presence\/absence at various stages of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Anosognosia Scale was given to 60 gene carriers (stratified by the HD Integrated Staging System (HD\u2010ISS), Total Functional Capacity (TFC), CAG\u2010Age\u2010Product (CAP), and composite UHDRS (cUHDRS) score) as well as their study partners. Differences between informant and patient scores of \u22656 points were considered evidence of anosognosia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>18% of participants in HD\u2010ISS stage 0\/1, 22% with TFC\u2009=\u200913, 37% who would be eligible for clinical trials (CAP score 400\u2013500), and 23% with a cUHDRS \u226514 displayed anosognosia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We conclude that anosognosia appears early in HD. This lack of awareness should dissuade against over\u2010reliance on self\u2010report instruments in HD clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70342","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T09:19:31Z","timestamp":1756718371000},"page":"1942-1946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How Early Does Anosognosia Begin in Huntington's Disease?"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6438-1844","authenticated-orcid":false,"given":"Krisha","family":"Bagga","sequence":"first","affiliation":[{"name":"Neurosciences UC San Diego  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Xu","sequence":"additional","affiliation":[{"name":"Neurosciences UC San Diego  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hall","sequence":"additional","affiliation":[{"name":"Neurosciences UC San Diego  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6553-0944","authenticated-orcid":false,"given":"Japleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Neurosciences UC San Diego  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Psychology San Diego State University  San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-8610","authenticated-orcid":false,"given":"Jody","family":"Corey\u2010Bloom","sequence":"additional","affiliation":[{"name":"Neurosciences UC San Diego  La Jolla CA 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