{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:04:45Z","timestamp":1785416685003,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K23NS121518"],"award-info":[{"award-number":["K23NS121518"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Scale for the Assessment and Rating of Ataxia (SARA) is the most used outcome measure in clinical trials for cerebellar ataxias. The minimal clinically important difference (MCID), a parameter used to assess meaningful change, is not clearly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To help define MCID for SARA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010two individuals with cerebellar ataxias participated in a home\u2010exercise clinical trial. Participants had outcomes assessed [SARA, Timed Up and Go (TUG), Dynamic Gait Index (DGI), gait speed, Patient Global Impression of Change (PGIC)] at 0\u2010, 6\u2010, 9\u2010, and 12\u2010months. Three methods were used to determine the MCID for SARA: anchor\u2010based method, distribution\u2010based method, and distribution\u2010based mapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The MCID for SARA using anchor\u2010based method was 1.75. The distribution\u2010based method and distribution\u2010based mapping identified a median MCID score of 1.23.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Synthesizing methods, we determined an MCID of 1.5 points. An accurate MCID is critical to ensure future treatments are clinically relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70343","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T09:10:59Z","timestamp":1757322659000},"page":"509-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Minimal Clinically Important Difference of the Scale for the Assessment and Rating of Ataxia"],"prefix":"10.1002","volume":"13","author":[{"given":"Gabriel","family":"Padilla","sequence":"first","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine\u2010 Elmira  Elmira New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biostatistics, College of Physicians and Surgeons Columbia University Medical Center  New York New York 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