{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:28:13Z","timestamp":1784608093627,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010NS89757"],"award-info":[{"award-number":["R01\u2010NS89757"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Quantitative susceptibility mapping (\n QSM<\/jats:styled-content>\n ) is a promising neuroimaging biomarker for detecting abnormal iron deposition in progressive supranuclear palsy (\n PSP<\/jats:styled-content>\n ); however, the\n QSM<\/jats:styled-content>\n profile and its accuracy in autopsy\u2010confirmed\n PSP<\/jats:styled-content>\n remain unexplored.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n The aim of the study was to elucidate and validate the QSM profiles in autopsy\u2010confirmed PSP.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eight patients with a clinically diagnosed\n PSP<\/jats:styled-content>\n syndrome (\n PSPS<\/jats:styled-content>\n ) underwent antemortem\n 3\u2009T<\/jats:styled-content>\n magnetic resonance imaging (\n MRI)<\/jats:styled-content>\n scanning and subsequent pathological diagnosis, confirming 6\n PSP<\/jats:styled-content>\n pathology and 2 multiple system atrophy (\n MSA<\/jats:styled-content>\n ) pathology cases.\n QSM<\/jats:styled-content>\n analysis and Prussian blue staining were performed across subcortical regions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PSP<\/jats:styled-content>\n cases showed higher susceptibility than age\u2010matched controls in the pallidum, subthalamic nucleus, substantia nigra, and cerebellar dentate (false discovery rate [\n FDR]<\/jats:styled-content>\n \u2010corrected\n P<\/jats:italic>\n \u2009<\u20090.05).\n PSP<\/jats:styled-content>\n had higher susceptibility in the subthalamic nucleus and lower susceptibility in the putamen than the clinically atypical\n MSA<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.08). Subcortical susceptibilities correlated with Prussian blue\u2013stained areas (\n r<\/jats:italic>\n \u2009=\u20090.63,\n P<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n QSM could be a reliable measure to evaluate abnormal iron accumulation patterns in PSP.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mdc3.70357","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:56:02Z","timestamp":1758124562000},"page":"785-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative Susceptibility Mapping and Iron Deposition in Autopsy\u2010Confirmed Progressive Supranuclear Palsy"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3418-2987","authenticated-orcid":false,"given":"Ryota","family":"Satoh","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester Minnesota 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