{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:58:42Z","timestamp":1779206322149,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>DOPA decarboxylase (DDC) in cerebrospinal fluid (CSF) is an emerging Parkinson's disease (PD) biomarker, but its association with nonmotor symptoms is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to determine if baseline DDC was associated with future cognitive decline in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We correlated baseline CSF DDC, detected using the proximity extension assay, with Montreal Cognitive Assessment (MoCA) score using longitudinal data from 3 cohorts: Biopark, PPMI, and PDBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DDC was significantly associated with cognitive decline in both the Biopark cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.0001) and the PDBP\/PPMI cohorts (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.0001). The results were still significant after correcting for levodopa\u2010equivalent daily dose in the Biopark cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.0001) and when the analysis was restricted to the de novo subjects, both in Biopark (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value: 0.0065) and PPMI (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value&lt;0.0001) cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CSF DDC is a potential biomarker for the prediction of cognitive decline in PD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70367","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:53:11Z","timestamp":1758707591000},"page":"791-794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Cerebrospinal\n                    <scp>DOPA<\/scp>\n                    Decarboxylase Level Predicts Cognitive Decline in Parkinson's Disease"],"prefix":"10.1002","volume":"13","author":[{"given":"Andrea","family":"Sturchio","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience, Neuro Svenningsson Karolinska Institutet  Stockholm Sweden"},{"name":"James J. and Joan A. Gardner Family Center for Parkinson's disease and Movement Disorders, Department of Neurology University of Cincinnati  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2141-4547","authenticated-orcid":false,"given":"Wojciech","family":"Paslawski","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Neuro Svenningsson Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shervin","family":"Khosousi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Neuro Svenningsson Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-5746","authenticated-orcid":false,"given":"Ioanna","family":"Markaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Neuro Svenningsson Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Nalls","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"},{"name":"DataTecnica LLC  Washington District of Columbia USA"},{"name":"Laboratory of Neurogenetics, National Institute on Aging National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew B.","family":"Singleton","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"},{"name":"Laboratory of Neurogenetics, National Institute on Aging National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"},{"name":"DataTecnica LLC  Washington District of Columbia USA"},{"name":"Laboratory of Neurogenetics, National Institute on Aging National Institutes of Health  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6727-3802","authenticated-orcid":false,"given":"Per","family":"Svenningsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Neuro Svenningsson Karolinska Institutet  Stockholm 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