{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:01:46Z","timestamp":1776063706675,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["PB\u2010PG\u2010112\u201029056"],"award-info":[{"award-number":["PB\u2010PG\u2010112\u201029056"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multidisciplinary care has been advocated for Juvenile\u2010onset Huntington's Disease but there has been no detailed analysis of this.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the current economic costs of providing health care for patients with Juvenile\u2010onset Huntington's disease (JoHD) and to model the effects and economic costs of providing a multidisciplinary team (MDT) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were recruited through the patients\u2019 organization, the Huntington's Disease Association, and specialist Huntington's disease clinics. Thirty\u2010three adapted Client Service Receipt Inventories were completed following either a telephone or in\u2010person interview. The effects of delivering two models of providing a systematic MDT approach, traditional in\u2010person MDT and digital MDT were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall mean JoHD cost to the NHS per year (2020) was \u00a3126,966 which varied according to disease severity, costing just under \u00a311,000 in mild disease, \u00a3132,419 in moderate disease, and \u00a3221,797 in advanced JoHD. The proportion of indirect costs to families and carers was 64% for mild disease and 17% for advanced disease. Assuming a 50% reduction in health care professionals seen, the alternative models saw reduction costs of \u00a32490 and \u00a32730, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We document the high cost of care in JoHD, particularly as the disease progresses towards the later stages. We present estimates from modeling the effects of providing a systematic MDT approach to the care of patients and families with JoHD. These data have clear implications in the consideration of future JoHD models of care in an increasingly digital age and can be developed further as disease modifying treatments become available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70433","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:07:37Z","timestamp":1762859257000},"page":"964-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Economic Cost of Current and Alternative Models of Multidisciplinary Care of Juvenile\u2010Onset Huntington's Disease"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-0471","authenticated-orcid":false,"given":"Tracey A.","family":"Young","sequence":"first","affiliation":[{"name":"Health Economics and Decision Science, Sheffield Centre for Health and Related Research, School of Medicine and Population Health University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny A.","family":"Curtis","sequence":"additional","affiliation":[{"name":"School of Allied Health Professions, Nursing and Midwifery University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9256-1208","authenticated-orcid":false,"given":"Jill","family":"Thompson","sequence":"additional","affiliation":[{"name":"School of Allied Health Professions, Nursing and Midwifery University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aileen K.","family":"Ho","sequence":"additional","affiliation":[{"name":"School of Psychology and Clinical Language Sciences University of Reading  Reading UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Santini","sequence":"additional","affiliation":[{"name":"Advisory Service, Huntington's Disease Association, Liverpool Science Park IC1  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-9051","authenticated-orcid":false,"given":"Oliver W.","family":"Quarrell","sequence":"additional","affiliation":[{"name":"Sheffield Children's Hospital, Western Bank  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60111-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3109"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781351208918-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-e"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/18796397251337000"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt.13.18"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-231523"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13255-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331912"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10505-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/18796397251319209"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13107"},{"key":"e_1_2_8_15_1","first-page":"163","volume-title":"Measuring Mental Health Needs","author":"Beecham J","year":"1992"},{"key":"e_1_2_8_16_1","unstructured":"NHS England.Data from: 2019\/20 National Cost Collection Data Publication;https:\/\/wwwenglandnhsuk\/publication\/2019-20-national-cost-collection-data-publication\/2021. 2019\/20. 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