{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:57:58Z","timestamp":1792893478840,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000304","name":"Parkinson's UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disord Clin Pract"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\u03b1\u2010synuclein seeding amplification assay (\u03b1\u2010synuclein SAA) development as a diagnostic biomarker for Parkinson's disease (PD) has shown promising results over the past decade. However, the utility of these assays in the prediction of disease progression is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the relationship between \u03b1\u2010synuclein SAA and PD\u2010specific clinical outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted longitudinal data on individuals with sporadic PD from the Parkinson's Progression Markers Initiative at baseline and 5\u2009years follow\u2010up. Primary outcome measures included MDS\u2010UPDRS Part III, Montreal Cognitive Assessment (MoCA) and L\u2010dopa equivalent daily dose (LEDD). Secondary outcome measures included REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) question\u20106 and other non\u2010motor assessments. \u03b1\u2010synuclein SAA kinetic parameters were added to linear regression models to assess their impact on model fit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 279 participants in the final analysis. There was no consistent evidence that \u03b1\u2010synuclein SAA parameters at baseline improved our prediction models for MDS\u2010UPDRS Part III, MoCA or LEDD at 5\u2009years. \u03b1\u2010synuclein SAA kinetic parameters improved model fit for RBDSQ question\u20106 and indicated that fast seeding profiles were associated with higher scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We did not find evidence of a relationship between \u03b1\u2010synuclein SAA and disease progression however \u03b1\u2010synuclein SAA was associated with RBDSQ. Further work is needed to understand the factors influencing \u03b1\u2010synuclein aggregation kinetics and the role of \u03b1\u2010synuclein SAA in disease prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mdc3.70434","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T11:08:31Z","timestamp":1763118511000},"page":"1228-1235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Role of \u03b1\u2010Synuclein Seed Amplification as a Disease Progression Marker: Evidence and Uncertainties"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-962X","authenticated-orcid":false,"given":"Daniel","family":"Belete","sequence":"first","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mattjie","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London  London United Kingdom"},{"name":"Machine Learning Theory and Application Research Laboratory, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5908-6983","authenticated-orcid":false,"given":"Brook","family":"Huxford","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Bestwick","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-5497","authenticated-orcid":false,"given":"Alastair J.","family":"Noyce","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of Population Health, Faculty of Medicine and Dentistry, Queen Mary University of London  London United Kingdom"},{"name":"Department of Neurology Royal London Hospital, Barts Health NHS Trust  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-0283","authenticated-orcid":false,"given":"Cristina","family":"Simonet","sequence":"additional","affiliation":[{"name":"Centre for Preventive Neurology, Wolfson Institute of 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